Program
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| Wednesday | Thursday | Friday |
Wednesday, 9 September
| 11:00 – 12:00 | Registration/light lunch |
| OSZ 1 |
Opening |
| 12:00 – 12:10 | Welcome to the Goethe University, Otto Stern Center Enrico Schleiff, Vice President, Goethe University |
| 12:10 – 12:20 | Thomas Braun (Acting President, GSCN) |
| 12:30 – 13:15 |
Keynote lecture I K1 – Epigenetic reactivation of adult epicardium underpins endogenous heart repair Paul Riley, University of Oxford, U.K. (Chair: Thomas Braun) |
| 13:15 – 14:00 | Keynote lecture II K2 – Modeling human lung development and disease using pluripotent stem cells Hans-Willem Snoeck, Columbia University, New York, U.S.A. (Chair: Ulrich Martin) |
| 14:00 – 14:30 |
Coffee break/industry exhibition |
| Concurrent scientific working group session I |
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| OSZ 3 |
Stem cells in regenerative therapies I (Chairs: Michael Cross/Ulrich Martin) Note: Session change – new presentation and speaker change |
| 14:30 – 14:45 | Overview Michael Cross, University of Leipzig |
| 14:45 – 15:00 | T01 – Pulmonary macrophage transplantation employing HSC- or iPSC-derived cells as an innovative gene therapy approach in Pulmonary Alveolar Proteinosis Nico Lachmann, Hannover Medical School |
| 15:00 – 15:15 | T02 – Cardiomyogenesis of human pluripotent stem cells is associated with transformation of metabolism and expression of specific PDLIM5 splice variants Sarah A. Konze, Hannover Medical School |
| 15:15 – 15:30 | T03 – Gene modification in stem cells targeting megakaryopoiesis Lisette Johanna Latorre Rey, Paul Ehrlich Institute, Langen |
| 15:30 – 15:45 | T04 – A novel cell surface marker for the enrichment of transplantable dopaminergic precursor cells from differentiated human pluripotent stem cells Andreas Bosio, Miltenyi Biotec GmbH, Bergisch Gladbach |
| 15:45 – 16:00 | Working group discussion “Stem cells in regenerative therapies” |
| OSZ 4 | Pluripotency and embryonic stem cells (Chairs: Hans Schöler/Mathias Treier) |
| 14:30 – 14:45 | Overview Hans Schöler, Max Planck Institute for Molecular Biomedicine, Münster |
| 14:45 – 15:00 | T05 – Foxd3 promotes the exit from naïve pluripotency and prevents germline specification through enhancer decommissioning Alvaro Rada-Iglesias, CMMC, University of Cologne |
| 15:00 – 15:15 | T06 – Ground state conditions induce rapid reorganization of core pluripotency factor binding before global epigenetic reprogramming Christina Galonska, Havard University, Cambridge, U.S.A. |
| 15:15 – 15:30 | T07 – TDP-43 safeguards pluripotency by regulation of alternative polyadenylation Miha Modic, Helmholtz Center Munich and MRC LMB Cambridge, U.K. |
| 15:30 – 15:45 | T08 – LncRNA Panct1 maintains mouse embryonic stem cell identity by recruiting TOBF1 to OCT-SOX sequences in early G1 Debojyoti Chakraborty, Dresden University of Technology |
| 15:45 – 16:00 | T09 – Decoding the heterogeneity of pluripotent stem cells at the single cell level Simon Hastreiter, ETH Zürich BSSE, Basel, Switzerland |
| OSZ 6 | Computational stem cell biology (Chairs: Georg Fuellen/Ingo Röder) |
| 14:30 – 14:45 | Overview Georg Fuellen, IBIMA, University of Rostock |
| 14:45 – 15:00 | T10 – Morpheus: computational modeling for stem cell biologists Walter de Back, Dresden University of Technology |
| 15:00 – 15:15 | T11 – Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy Michael Strasser, Helmholtz Center Munich |
| 15:15 – 15:30 | T12 – Prospective identification of hematopoietic lineage choice Carsten Marr, Helmholtz Center Munich |
| 15:30 – 15:45 | T13 – On the quantification of hematopoietic tissue remodeling in aging and disease: simulations, measures and predictions Christoph Baldow, Dresden University of Technology |
| 15:45 – 16:00 | Working group discussion “Computational stem cell biology” |
| 16:00 – 16:30 | Coffee break/industry exhibition |
| 16:30 – 18:30 | Poster session I: P001 – P074 P001 – P024: Hematopoietic stem cells P025 – P038: Stem cells in regenerative therapies P039 – P048: Stem cells in regenerative therapies: Mesenchymal stem/stroma cells P049 – P074: Stem cells in disease modeling and drug development Even numbers: please present your poster from 16:30 – 17:30 Odd numbers: 17:30 – 18:30 |
| 18:30 – 21:00 | Informal GSCN Get together for all participants with dinner buffet at the foyer of the Otto Stern Center |
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Thursday, 10 September
| Concurrent scientific working group session II |
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| OSZ 3 | Stem cells in disease modeling and drug development (Chairs: Karl-Ludwig Laugwitz/Oliver Brüstle) | |
| 09:00 – 09:15 | Overview Karl-Ludwig Laugwitz, Technische Universität München |
|
| 09:15 – 09:30 | T14 – Infection, innate immune signaling and cancer in the stomach – stem cell-derived organoids as a new model Sina Bartfeld, Hubrecht Institute, Utrecht, Netherlands |
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| 09:30 – 09:45 | T15 – Modeling reactive gliosis in mESC-derived retina organoids Manuela Völkner, DZNE Dresden |
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| 09:45 – 10:00 | T16 – Patient iPSC-derived NPCs as a model for mtDNA mutations reveal HCS/HTS-suitable phenotypes Raul Bukowiecki, Max Delbrück Center, Berlin |
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| 10:00 – 10:15 | T17 – Intracellular calcium-release and autophagy modulation trigger ataxin-3 positive nuclear inclusions in Machado-Joseph disease-specific neurons Johannes Jungverdorben, Institute of Reconstructive Neurobiology, Bonn |
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| 10:15 – 10:30 | Working group discussion “Stem cells in disease modeling and drug development” | |
| OSZ 4 |
Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz/Andreas Trumpp) |
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| 09:00 – 09:15 | Overview Thomas Brabletz, FAU Erlangen |
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| 09:15 – 09:30 | T18 – Epigenetic age-predictions in cancer: aging signatures are associated with malignant transformation and clinical prognosis Wolfgang Wagner, RWTH Aachen Medical School |
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| 09:30 – 09:45 | T19 – Triple-negative inflammatory breast cancer: syndecan-1 is a biomarker and regulator of cancer stem cell phenotype via IL-6/STAT-3 and Notch-3 Sherif A. Ibrahim, Faculty of Science, Cairo University, Egypt |
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| 09:45 – 10:00 | T20 – Targeting tumor-initiating stem cells in colorectal carcinoma Ilaria Lunger, Goethe University Hospital and LOEWE Center Frankfurt |
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| 10:00 – 10:15 | T21 – Unraveling the subclonal architecture of adult B-ALL at a single cell level Bartosch Wojcik, Goethe University Hospital and LOEWE Center Frankfurt |
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| 10:15 – 10:30 | Working group discussion “Stem cells in disease: cancer stem cells” | |
| OSZ 6 |
Stem cells in development (Chairs: Jan Lohmann/Thomas Braun) | |
| 09:00 – 09:15 | Overview Jan Lohmann, Centre for Organismal Studies (COS) Heidelberg |
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| 09:15 – 09:30 | T22 – Understanding the curious case of trophoblast differentiation Micha Drukker, Helmholtz Center Munich |
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| 09:30 – 09:45 | T23 – The Ca2+-regulated phosphatase calcineurin controls proportional growth of zebrafish regenerating fins Christopher Antos, DFG-Center for Regenerative Therapies/ TU Dresden |
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| 09:45 – 10:00 | T24 – Antagonistic roles of miR-181a and orphan nuclear receptor GCNF in regulating human neural stem cell maintenance Laura Stappert, Institute of Reconstructive Neurobiology, Bonn |
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| 10:00 – 10:15 | T25 – Direct Nkx2-5 transcriptional repression of Isl1 controls cardiomyocyte subtype identity Jessica Haas, Klinikum r.d.I. der TUM, Muinch |
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| 10:15 – 10:30 | T26 – Hypoxia induced epigenetic mechanism underlying Isl1+ cardiac progenitor cell homeostasis control Xuejun Yuan, Max Planck Institute for Heart and Lung Research, Bad Nauheim |
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| 10:30 – 11:00 |
Coffee break/industry exhibition |
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| Industry session: “Technologies from GSCN industry partners” | |
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| OSZ 3 |
Main supporters (Chair: Albrecht Müller) | |
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C1 – Robust expansion of human pluripotent stem cells: integration of bioprocess design with transcriptomic and metabolomic characterization Margarida Serra, Instituto de Tecnologia Química e Biológica (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal, representing Eppendorf AG |
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| 11:35 – 12:05 | C2 – A human iPS cell platform to study pancreatic disease Alexander Kleger, University Hospital Ulm, representing PeproTech GmbH |
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| 12:05 – 12:35 | C3 – Advances in pluripotent stem cell culture and differentiation David Kuninger, Thermo Fisher Scientific/Life Technologies GmbH |
|
| OSZ 4 |
Supporters (Chair: Hartmut Geiger) |
|
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C4 – Consistency of pluripotent stem cell culture systems and differentiation protocols for generation of functional human stem cell derived hepatocytes Mia Emgård, Takara Clontech |
|
| 11:35 – 12:05 | C5 – Reprogramming of somatic cells to induced pluripotent stem cells using a novel synthetic self-replicating RNA vector in a feeder-free system Alexandra Blak, STEMCELL Technologies SARL |
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| 12:05 – 12:35 | C6 – High throughput electrospinning to generate scaffolds containing cells for regenerative medicine applications Thomas Hayes, BioInicia S.L./I&L Biosystems GmbH |
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| OSZ 6 |
Supporters (Chair: Ana Martin-Villalba) | |
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C7 – An optimal serum-free, xeno-free culture system for the isolation, expansion and differentiation of clinical grade human mesenchymal stem cells Orit Ecker-Cohen, Biological Industries/Biofroxx GmbH |
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| 11:35 – 12:05 | C8 – Explore what makes every stem cell unique from the inside out Mark Lynch, Fluidigm Europe B.V. |
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| 12:05 – 12:35 | C9 – GrowDex® hydrogel for 3D cell cultures Lauri Paasonen, UPM-Kymmene Corporation |
|
| 12:35 – 14:00 |
Lunch buffet/industry exhibition/poster viewing |
|
| 12:50 – 13:45 | Showcase: Outreach + Patient Information (Chairs: Ira Herrmann/Tobias Cantz) | |
| OSZ 1 |
Presidential Symposium (Chair: Thomas Braun) | |
| 14:00 – 14:30 |
PS1 – Evolving stem cell-based strategies for targeting neurological disorders Oliver Brüstle, Institute of Reconstructive Neurobiology, Bonn |
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| 14:30 – 15:00 | Young Investigator Award PS2 – In vitro cell culture models to decipher brain development and neuronal integration Julia Ladewig, Institute of Reconstructive Neurobiology, Bonn |
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| 15:00 – 15:30 |
Female Scientist Award PS3 – From neurogenesis to neural repair Magdalena Götz, Helmholtz Center Munich |
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| 15:30 – 16:00 | Publication of the Year 2015 Award (June 2014 – 2015) PS4 – Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells Jichang Wang (w. Zsuzsanna Izsvak), Max Delbrück Center, Berlin |
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| 16:00 – 16:30 |
Coffee break/industry exhibition |
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| 16:30 – 18:30 | Poster session II: P075 – P147 P075 – P093: Pluripotency and embryonic stem cells P094 – P107: Programing and Reprograming P108 – P113: Somatic stem cells P114 – P130: Stem cells in development P131 – P143: Stem cells in disease: Cancer stem cells P144 – P147: Computational stem cell biology Even numbers: please present your poster from 16:30 – 17:30 Odd numbers: 17:30 – 18:30 |
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| 18:30 – 19:30 | Membership meeting |
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| 19:30 – 20:00 | Bus transfer | |
| 20:00 – 01:00 |
GSCN Networking evening for all participants with dinner buffet and DJ at the Banquet Hall I, Casino, Campus Westend |
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Friday, 11 September
| Concurrent scientific working group session III | |
| OSZ 3 | Hematopoietic stem cells (Chairs: Timm Schroeder/Claudia Waskow) |
| 09:00 – 09:15 | Overview Timm Schroeder, ETH Zürich BSSE, Basel, Switzerland |
| 09:15 – 09:30 | T27 – CCND1/CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem and progenitor cells in vivo Nicole Mende, Dresden University of Technology |
| 09:30 – 09:45 | T28 – The H3K4 histone methyltransferase Setd1b is required for haematopoietic stem cell homeostasis in mice Kerstin Schmidt, Biotechnology Center TU Dresden |
| 09:45 – 10:00 | T29 – Molecular and functional heterogeneity of dormant HSCs Nina Cabezas-Wallscheid, German Cancer Research Center (DKFZ) Heidelberg |
| 10:00 – 10:15 | T30 – High efficiency gene correction in hematopoietic cells by template-free CRISPR/Cas9 genome editing Frank Schnütgen, University Hospital Frankfurt |
| 10:15 – 10:30 | Working group discussion “Basic, translational and applied hematopoiesis” |
| OSZ 4 | Somatic stem cells (Chairs: Ana Martin-Villalba/Michael Rieger) |
| 09:00 – 09:15 | Overview Ana Martin-Villalba, German Cancer Research Center (DKFZ) Heidelberg |
| 09:15 – 09:30 | T31 – Visualization of the short-range Wnt gradient in the intestinal stem cell niche Henner Farin, Georg-Speyer-Haus, Frankfurt |
| 09:30 – 09:45 | T32 – Clonal heterogeneity within the exocrine pancreas Damian Wollny, German Cancer Research Center (DKFZ) Heidelberg |
| 09:45 – 10:00 | T33 – Single cell analysis of cellular mechanisms regulating adult neural stem cell fate Onur Basak, Hubrecht Institute, Utrecht, Netherlands |
| 10:00 – 10:15 | T34 – In vivo Ribotag analysis reveals translational control during neural stem cell differentiation Avni Baser, German Cancer Research Center (DKFZ) Heidelberg |
| 10:15 – 10:30 | Working group discussion “Somatic stem cells and development” |
| OSZ 5 |
Stem cells in reg. therapies II: Mesenchymal stem/stroma cells (Chairs: Dirk Strunk/Karen Bieback) |
| 09:00 – 09:15 | Overview Dirk Strunk, Paracelsus Medical University, Salzburg, Austria |
| 09:15 – 09:30 | T35 – The transcription factor GATA2 controls mesenchymal stem cell fate Alexander Tolkachov, Center for Cardiovascular Research, Charité, Berlin |
| 09:30 – 09:45 | T36 – Attenuation of alloimmunity to human endothelial colony forming cells (ECFC) by interaction with mesenchymal stem/progenitor cells (MSPC) Naima Souidi, Berlin-Brandenburg Center for Regenerative Medicine and Institute of Medical Immunology, Charité, Berlin |
| 09:45 – 10:00 | T37 – Murine bone marrow derived mesenchymal stem cells as a putative therapy approach for influenza-virus induced pneumonia Lina Jankauskaite, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen |
| 10:00 – 10:15 | T38 – Regenerative potential of human pluripotent stem cell-derived MSCs in a Gunn rat liver injury model Lucas-Sebastian Spitzhorn, University Hospital of Düsseldorf |
| Working group discussion “Stem cells in regenerative therapies” – future progress with MSCs | |
| OSZ 6 | Programing and reprograming (Chairs: Micha Drukker/Frank Edenhofer) |
| 09:00 – 09:15 | Overview Micha Drukker, Helmholtz Center Munich |
| 09:15 – 09:30 | T39 – An inducible overexpression system for rapid and highly efficient induction of mature cell types from human pluripotent stem cells Matthias Pawlowski, Cambridge Stem Cell Institute, U.K. |
| 09:30 – 09:45 | T40 – Reprogramming triggers endogenous LINE-1, Alu and SVA retrotransposition in human induced pluripotent stem cells affecting host gene expression Gerald Schumann, Paul Ehrlich Institute, Langen |
| 09:45 – 10:00 | T41 – Efficient patterning of human pluripotent stem cells towards distinct mesendodermal subtypes simply by modulation of the bulk cell density Henning Kempf, Hannover Medical School |
| 10:00 – 10:15 | T42 – Direct in vivo glia-to-neuron conversion in the postnatal mouse cerebral cortex Sophie Péron, Institute of Physiological Chemistry, Johannes Gutenberg University Mainz |
| 10:15 – 10:30 | Working group discussion “Pluripotency and reprograming” |
| 10:30 – 11:00 |
Coffee break/industry exhibition |
| Concurrent strategic working group session |
|
| OSZ 3 | Stem cell technologies (Chairs: Frank Emmrich/Andreas Bosio) |
| 11:00 – 11:30 | S1 – Technologies in genetic engineering of stem cells Ulrich Martin, Hannover Medical School |
| 11:30 – 12:00 | S2 – Genetic engineering of human pluripotent stem cells using TALENs nucleases Sebastian Diecke, Max Delbrück Center, Berlin |
| 12:00 – 12:30 | S3 – Mammalian genome engineering in the era of CRISPR/Cas Ralf Kühn, Max Delbrück Center, Berlin |
| OSZ 4 | Career development (Chairs: Insa Schröder/Hartmut Geiger) |
| 11:00 – 11:15 | Introduction Insa Schröder, GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt |
| 11:15 – 12:00 | S4 – How to apply in research and industry Hanna Proner, academics/Die Zeit, Hamburg |
| 12:00 – 12:30 | Panel discussion |
| OSZ 5 |
Clinical trials and regulatory affairs (Chairs: Andreas Kurtz/Halvard Bönig) |
| 11:00 – 11:05 | Introduction Andreas Kurtz, Berlin-Brandenburg Center for Regenerative Medicine, Charité, Berlin |
| 11:05 – 11:25 | S5 – Regulatory aspects and classifications of stem cell based medicinal products Egbert Flory, Paul Ehrlich Institute, Langen |
| 11:25 – 11:45 | S6 – Accelerating the clinical development of cell based therapies Natalie Mount, Cell Therapy Catapult, London, U.K. |
| 11:45 – 12:00 | S7 – The ADIPOA-1/-2 trial – Adipose tissue derived stromal cells for osteoarthritis therapy Oliver Pullig, Fraunhofer IGB, Würzburg branch |
| 12:00 – 12:15 | S8 – Cell Therapy for bone defects: in vitro, in vivo, and first clinical results Ingo Marzi, Goethe University Hospital, Frankfurt |
| 12:15 – 12:30 | Panel discussion |
| 12:30 – 14:00 |
Lunch buffet/industry exhibition/poster viewing |
| 12:45 – 13:45 | Meet-the-expert table: Stem cell technologies – CRISPR/Cas Technology (Ralf Kühn) and – TALENs Technology (Sebastian Diecke) limited to 10 registered participants each |
| 12:45 – 13:45 | Drop-in booth on regulatory affairs and clinical trials with Egbert Flory, Natalie Mount, u.a. |
| OSZ 1 | Joined session with LOEWE Center for Cell and Gene Theraty Frankfurt (CGT) |
| 14:00 – 14:45 |
Keynote lecture III K3 – Pluripotency in the artificial cell space Andras Nagy, Lunenfeld-Tanenbaum Research Institute, Toronto, Canada (Chair: Harald von Melchner) |
| 14:45 – 15:30 |
Keynote lecture IV K4 – Modeling and treating neural disease using human pluripotent stem cells Lorenz Studer, Memorial Sloan Kettering Cancer Center, New York (Chair: Lenhard Rudolph) |
| 15:30 – 16:00 |
Coffee break/industry exhibition |
| OSZ 1 | CGT Session (Chair: Lenhard Rudolph) |
| 16:00 – 16:20 | CGT1 – Regulation of second heart field progenitor cells: discovering key molecular players Gergana Dobreva, Max Planck Institute for Heart and Lung Research, Bad Nauheim |
| 16:20 – 16:40 | CGT2 – Functional systems analysis of the adult muscle stem cell identifies crucial regulators of muscle regeneration Johnny Kim, Max Planck Institute for Heart and Lung Research, Bad Nauheim |
| 16:40 – 17:00 | CGT3 – Hematopoietic stem cell fate decision control at single cell resolution Michael Rieger, Goethe University Hospital and LOEWE Center Frankfurt |
| 17:00 – 17:20 | CGT4 – The Sleeping Beauty transposon system for genetic engineering in stem cells Zoltán Ivics, Paul Ehrlich Institute, Langen |
| OSZ 1 | Closing ceremony |
| 17:30 – 17:45 | Poster award ceremony and announcement of industry quiz winners (Daniel Besser; GSCN) supported by PeproTech GmbH |
| 17:45 – 18:00 | Outlook and closing remarks Incoming president: Ulrich Martin |
| End of GSCN conference 2015 |
|
| Announcement: | |
| 19:00 – 20:00 | GSCN Public outreach event at the Hall West, Campus Westend |
| 20:00 – 21:00 | Reception public outreach event |
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Supporters
© German Stem Cell Network (GSCN) e.V., 2015
Last updated 06/11/2015
Last updated 06/11/2015