Program
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GSCN Conference 2013 Report (PDF, 2.6 MB)
| Monday | Tuesday | Wednesday |
Monday, November 11th
| 12:00 – 13:00 | Registration |
| Opening | |
| 13:00 – 13:10 | Welcome to the Max Delbrück Center: Walter Rosenthal (Scientific Director, MDC) |
| 13:10 – 13:30 |
A Stem Cell Network for Germany – why the time is just right Oliver Brüstle (Acting President, GSCN) |
| 13:30 – 14:30 | Keynote lecture I K1 – Regenerative medicine by somatic stem cells: The paradigm of epithelial cells Michele de Luca; Center for Regenerative Medicine “Stefano Ferrari”, Modena, Italy (Chair: Frank Emmrich) |
| 14:30 – 15:00 | Coffee break / Industry Exhibition |
| 15:00 – 16:00 | Keynote lecture II K2 – In vivo phenotypic and functional stability of iDA neurons and chemo-genetic enhancement of their therapeutic potential Vania Broccoli; San Raffaele Scientific Institute, Milan, Italy (Chair: Mathias Treier) |
| 16:00 – 16:30 | Introduction of the GSCN strategic working groups |
| 16:30 – 19:00 | Poster session I: P001 – P094 P001 – P019: Pluripotency and embryonic stem cells P020 – P052: Programing and reprograming P053 – P072: Stem cells in development P073 – P081: Stem cells in tissues of neural and non-neural ectoderm P082 – P094: Stem cells in tissues of meso- and endodermal origin |
| 19:00 | Bus shuttle to event location |
| 20:00 – 00:30 | Networking evening with dinner buffet at eventlocation “Alte Pumpe” Lützowstr. 42, 10785 Berlin (www.altepumpe.de) (Opening: Albrecht Müller) (included in the registration fee) |
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Tuesday, November 12th
| Concurrent scientific working group session I |
|
| Axon 1*: | Pluripotency and embryonic stem cells (chair: Mathias Treier / James Adjave) |
| 09:30 – 09:40 | Introduction |
| 09:40 – 10:00 | T01 – Loss of Myc activity induces cellular dormancy in ES cells cultured in 2i mimicking the status of diapause embryos Roberta Scognamiglio; German Cancer Research Center, Heidelberg |
| 10:00 – 10:20 | T02 – Epigenetic regulation of lineage commitment Gunnar Schotta; Adolf Butenandt Institute, LMU Munich |
| 10:20 – 10:40 | T03 – Mll2 is the H3K4 trimethyltransferase for bivalent promoters in mouse embryonic stem cells A. Francis Stewart; Technical University Dresden |
| 10:40 – 11:00 | Group discussion |
| Axon 2: | Cancer stem cells in solid tumors (chair: Andreas Trumpp / Thomas Brabletz) |
| 09:30 – 09:40 | Introduction |
| 09:40 – 10:00 | T04 – The KC/IL8-mTOR axis activates stem cell maintenance and chemotherapy resistance of hepatic tumor-initiating cells Uta Kossatz-Böhlert; University Tübingen |
| 10:00 – 10:20 | T05 – The role of EVI1 in breast cancer cells Hui Wang; University Hospital Basel, Switzerland |
| 10:20 – 10:40 | T06 – Patient derived models for pancreatic cancer reveal four molecular subtypes associated with differential drug response and clinical outcome Elisa Noll; HI-STEM, Heidelberg |
| 10:40 – 11:00 | Group discussion |
| Dendrit 2/3: | Stem cells in tissues of meso- and endodermal origin (chair: Thomas Braun / Heiko Lickert) |
| 09:30 – 09:40 | Introduction |
| 09:40 – 10:00 | T07 – A lentiviral RNAi screen against the muscle stem cell proteome identifies novel regulators governing muscle regeneration Johnny Kim; MPI f. Heart and Lung Research, Bad Nauheim |
| 10:00 – 10:20 | T08 – Direct lineage conversion of liver to pancreas Francesca M. Spagnoli; Max Delbrück Center, Berlin |
| 10:20 – 10:40 | T09 – Early Growth Response transcription factors Egr1 and Egr2 regulate lineage commitment of bone marrow mesenchymal stromal progenitors Konstantinos Anastassiadis; BIOTEC, Technical University Dresden |
| 10:40 – 11:00 | Group discussion |
| 11:00 – 11:30 | Coffee break / Industry exhibition |
| Concurrent strategic working group session A |
|
| Axon 1: | Career development (chairs: Insa Schröder / NN) |
| 11:30 – 11:50 | I1 – Alternative career pathways for life scientists Thorsten Abs; academics GmbH, Hamburg |
| 11:50 – 12:30 | Group / panel discussion |
| Axon 2: | Funding programs/policies (chairs: Albrecht Müller / Ulrich Martin) |
| 11:30 – 11:50 | I2 – Horizon 2020 – News on EU research funding Jürgen Sautter; European Commission, Brussels, Belgium |
| 11:50 – 12:30 | Group / panel discussion |
| Dendrit 2/3: | Outreach activities and public perception of stem cell therapies (chair: Tobias Cantz / Ira Herrmann) |
| 11:30 – 11:40 | Introduction (Tobias Cantz) |
| 11:40 – 11:55 | I3: EuroStemCell Toolkit for Public Engagement: Information, Education, Conversation Emma Kemp, EuroStemCell, Edinburgh, United Kingdom |
| 11:55 – 12:10 | I4: Ethical aspects of innovative therapies Gisela Badura-Lotter, University Ulm |
| 12:10 – 12:30 | Group/panel discussion |
| 12:30 – 13:30 | Lunch buffet / Industry exhibition |
| Concurrent strategic working group session B | |
| Axon 1: | Stem cell technologies (chair: Frank Emmrich / Andreas Bosio) |
| 13:30 – 13:50 | I5: Stem cell technologies Andreas Bosio; Miltenyi, Berg. Gladbach, and Frank Emmrich; University Leipzig |
| 13:50 – 14:30 | Group/panel discussions |
| Axon 2: | Clinical trials and regulatory affairs (chair: Torsten Tonn / Andreas Kurtz) |
| 13:30 – 13:50 | I6: Implementation of cell- and gene therapy for clinical application: challenges and regulatory requirements Christine Günther; Apceth GmbH & Co. KG, Ottobrunn |
| 13:50 – 14:30 | Group/panel discussions |
| 14:30 – 14:45 | Short break |
| Concurrent scientific working group session II | |
| Axon 1: | Stem cells in regenerative therapies (chair: Michael Cross / Ulrich Martin) |
| 14:45 – 14:55 | Introduction |
| 14:55 – 15:15 | T10 – Transplantation of genetically corrected human iPSC-derived neural stem cells in a mouse model of metachromatic leukodystrophy Jonas Doerr; Institute of Reconstructive Neurobiology, Bonn |
| 15:15 – 15:35 | T11 – MicroRNA-199a-5p: A novel regulator of differentiation of hepatocytes from embryonic stem cells Selina Möbus; REBIRTH, MH Hannover |
| 15:35 – 15:55 | T12 – Successful treatment of therapy-refractory acute Graft-versus-Host disease with mesenchymal stem cell-derived exosomes Bernd Giebel; Institute for Transfusion Medicine, Essen |
| 15:55 – 16:15 |
Group discussion |
| Axon 2: | Programing and reprograming (chair: Micha Drukker / Frank Edenhofer) |
| 14:45 – 14:55 | Introduction |
| 14:55 – 15:15 | T13 – Analysis of signaling framework governing cardiac specification of human pluripotent stem cells Boris Greber; MPI f. molecular Biomedicine, Münster |
| 15:15 – 15:35 | T14 – Generation of mature megakaryocytes from human pluripotent stem cells by a transcription factor mediated forward programming approach Thomas Moreau; University of Cambridge, United Kingdom |
| 15:35 – 15:55 | T15 – A DNA methylation motifs discovery algorithm reveals the crosstalk among DNA methylation, transcription factors and histone marks in pluripotent cells Marcos J. Arauzo-Bravo; MPI f. molecular Biomedicine, Münster |
| 15:55 – 16:15 | Group discussion |
| Dendrit 2/3: | Stem cells in tissues of neural and non-neural ectoderm (chair: Walter Birchmeier / Ana Martin-Villalba) |
| 14:45 – 14:55 | Introduction |
| 14:55 – 15:15 | T16 – Clonal lineage tracing of adult neural stem cells reveals features of adult neurogenesis Filippo Calzolari; Helmholtz Center Munich |
| 15:15 – 15:35 | T17 – The inflammatory gene AKNA, an at-hook containing transcription factor, regulates differentiation and survival of neural stem cells Pia Johansson; Helmholtz Center Munich |
| 15:35 – 15:55 | T18 – Oligodendrogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt Benedikt Berninger; University Mainz |
| 15:55 – 16:15 | Group discussion |
| 16:15 – 18:45 | Poster session II: P095 – P193 P095 – P116: HSCs and stem cells in hematopoietic malignancies P117 – P128: Cancer stem cells in solid tumors P129 – P166: Stem cells in regenerative therapies P167 – P193: Stem cells in disease modeling and drug development |
| 18:45 – 19:30 | Dinner buffet |
| 19:30 – 21:00 | Convention of GSCN members |
| 21:00 – 22:00 | Informal GSCN get-together (MDC.C Foyer) |
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Wednesday, November 13th
| Concurrent scientific working group session III | |
| Axon 1: | Stem cells in disease modeling and drug development (chair: Karl-Ludwig Laugwitz / Oliver Brüstle) |
| 09:00 – 09:10 | Introduction |
| 09:10 – 09:30 | T19 – Induction of nuclear ataxin-3 inclusions in Machado-Joseph disease-specific neurons Johannes Jungverdorben (Inst. of Reconstructive Neurobiology, Bonn) |
| 09:30 – 09:50 | T20 – Restoration of GM-CSF depended functionalities in macrophages utilizing patient specific iPSC from a congenital pulmonary alveolar proteinosis patient Nico Lachmann (MHH, Hannover) |
| 09:50 – 10:10 | T21 – Raman spectroscopy as novel marker for sensitive stem cell identification Karin Schütze (CellTool GmbH, Bernried) |
| 10:10 – 10:30 | Group discussion |
| Axon 2: | Stem cells in development (chair: Elly Tanaka / Jan Lohmann) |
| 09:00 – 09:10 | Introduction |
| 09:10 – 09:30 | T22 – Tet-dependent processing of 5-methylcytosine, epigenetic stability and the maintenance of active higher order structures during differentiation Achim Breiling (German Cancer Research Center, Heidelberg) |
| 09:30 – 09:50 | T23 – Aldh1b1 regulates the timing in pancreas lineage segregation and beta cell maturation Elpinki Ninou (Paul Langerhans Institute, Dresden) |
| 09:50 – 10:10 | T24 – A transitional extracellular matrix instructs regenerative cell behavior Hans-Georg Simon (Northwestern University, Chicago) |
| 10:10 – 10:30 | Group discussion |
| Dendrit 2/3: | HSCs and stem cells in hematopoietic malignancies (chair: Anthony Ho / Timm Schröder) |
| 09:00 – 09:10 | Introduction |
| 09:10 – 09:30 | T25 – The genome wide molecular landscape of hematopoietic stem cells and their immediate progeny Nina Cabezas-Wallscheid (DKFZ, Heidelberg) |
| 09:30 – 09:50 | T26 – Crosstalk between WNT/β-catenin and IRF8 in hematopoiesis and leukemia Marina Scheller (UKE, Hamburg) |
| 09:50 – 10:10 | T27 – A stem cell intrinsic switch from canonical to non-canonical Wnt signaling regulates aging of hematopoietic stem cells Maria Carolina Florian (University Ulm) |
| 10:10 – 10:30 | Group discussion |
| 10:30 – 11:00 | Coffee break / Industry exhibition |
| Industry session: “Technologies from GSCN industry partners” | |
| Axon 1: | Main supporters |
| 11:00 – 11:05 | Introduction (Mathias Treier) |
| 11:05 – 11:35 | C1 – Development of a new serum-free media for the cultivation of pluripotent stem cells Bärbel Icheln, Peprotech GmbH |
| 11:35 – 12:05 | C2 – Novel reagents for pluripotent stem cell research and differentiation to neural lineages Mohan C. Vemuri, Life Technologies GmbH |
| 12:05 – 12:35 | C3 – Gene expression analysis down to the single cell level by digital quantification utilizing the nCounter system Maik Prüß; Nanostring Tech. LTD |
| Axon 2: | Supporters |
| 11:00 – 11:05 | Introduction (Ulrich Martin) |
| 11:05 – 11:35 | C4 – Flow cytometry applications for isolating and analyzing complex heterogeneous stem cell cultures Yannick Marari, BD Biosciences |
| 11:35 – 12:05 | C5 – Suspension culture and cardiomyogenic differentiation of human pluripotent stem cells in stirred bioreactor systems Robert Zweigerdt, MH Hannover, representing Eppendorf AG |
| 12:05 – 12:35 | C6 – Pharmaceutical stem cell therapy for advanced diseases entering clinical application Veronika Reiter, Apceth GmbH & Co. KG |
| Dendrit 2/3: | Supporters |
| 11:00 – 11:05 | Introduction (Michael Cross) |
| 11:05 – 11:35 | C7 – Discover a New Approach to Single-Cell Genomics with the C1™ Single-Cell Auto Prep System Fluidigm, Europe B.V. |
| 11:35 – 12:05 | C8 – The IncuCyte system – new applications for iPSC production Peter K. Djali, Essen BioScience Ltd. |
| 12:05 – 12:35 | C9 – Development of extracellular matrices for stem cell culture Maja Petkovic, AMS Biotechnology (Europe) Limited |
| 12:35 – 14:00 | Lunch buffet / industry exhibition |
| 14:00 – 15:00 | Keynote lecture III |
| K3 – Cardiomyocytes from human pluripotent stem cells: the new patient in safety pharmacology, drug discovery and disease Christine Mummery; Leiden University Medical Center, Netherlands (Chair: Andreas Trumpp) |
|
| 15:00 – 15:30 | Coffee break / industry exhibition |
| 15:30 – 16:30 | EMBO Lecture |
| K4 – Design principles of pluripotency Austin Smith; Wellcome Trust-MRC Stem Cell Institute, University of Cambridge, United Kingdom (Chair: Oliver Brüstle) |
|
| Closing ceremony | |
| 16:30 – 16:45 | Poster award ceremony (Daniel Besser, GSCN) |
| 16:45 – 17:00 | Outlook and closing remarks Andreas Trumpp (Incoming president, GSCN) |
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Supporters
© Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, 2013
Last updated 07/01/2013
Last updated 07/01/2013
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