Program
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| Monday | Tuesday | Wednesday |
Monday, 12 September
| 10:00 – 11:00 | Registration |
| Lecture hall F |
Opening |
| 11:00 – 11:10 | Welcome to Hannover Medical School (MHH) Christopher Baum, President, Hannover Medical School |
| 11:10 – 11:20 | Welcome to Hannover and Lower Saxony MPräs. Stephan Weil (Minister-President of Lower Saxony) |
| 11:20 – 11:30 | Ulrich Martin, Acting President, GSCN |
| 11:30 – 12:15 |
Keynote lecture I K1 – Mechanisms of epigenetic regulation in stem cells and development Alexander Meissner, Harvard University, Cambridge, U.S.A. (Chair: Ulrich Martin) |
| 12:15 – 13:00 | Keynote lecture II K2 – Identification of niches for hematopoietic stem cells and osteogenesis Sean Morrison, UT Southwestern, Dallas, U.S.A. (Chair: Claudia Waskow) |
| 13:00 – 14:00 |
Lunch break / Industry exhibition |
| Concurrent scientific working group session I |
|
| Lecture hall H |
Stem cells in regenerative therapies I (Chairs: Wolfgang Wagner/Ulrich Martin) |
| 14:00 – 14:15 |
Overview Wolfgang Wagner, RWTH Aachen |
| 14:15 – 14:30 |
T01 – HLA-silenced platelets derived from induced pluripotent stem cells are protected against refractoriness in a platelet transfusion mouse model Dorothee Eicke, Hannover Medical School |
| 14:30 – 14:45 |
T02 – Immunogenicity of embryonic stem cell-derived cardiomyocytes in recipients mismatched for minor and major histocompatibility antigens Birte Baudis, University of Cologne |
| 14:45 – 15:00 |
T03 – BSA-free differentiation of hPSCs into cardiomyocytes Hanna Möller, Hannover Medical School |
| 15:00 – 15:15 |
T04 – A registry of pluripotent stem cells for clinical application Andreas Kurtz, Berlin-Brandenburg Center for Regenerative Therapies, Charité, Berlin |
| 15:15 – 15:30 |
Working group discussion |
| Lecture hall G | Pluripotency and reprograming (Chairs: Micha Drukker/Mathias Treier) |
| 14:00 – 14:25 |
T05 – Pluripotency keynote – Trophoblast stem cells from murine fibroblasts – can the mouse serve as blueprint for the human situation? Hubert Schorle, University of Bonn |
| 14:25 – 14:40 |
T06 – Nanotopography guides morphology and spatial patterning of induced pluripotent stem cell colonies Giulio Abagnale, RWTH Aachen |
| 14:40 – 14:55 |
T07 – Propagation of the early murine inner cell mass state in cell culture Xiushan Yin, Max Delbrück Center, Berlin |
| 14:55 – 15:10 |
T08 – Contribution of cynomolgus monkey induced pluripotent stem cells to porcine embryos Monika Nowak-Imialek, Friedrich Loeffler Institute, Mariensee |
| 15:10 – 15:25 |
T09 – Characterization and potential immunomodulatory properties of human induced pluripotent stem cell (hiPSC)-derived trophoblast cells Svitlana Malysheva, Hannover Medical School |
| 15:25 – 15:30 |
Working group discussion |
| Lecture hall M | Hematopoietic stem cells (Chairs: Timm Schröder/Claudia Waskow) |
| 14:00 – 14:25 |
T10 – HSC keynote – Hematopoietic stem cell fate realized in vivo Hans-Reimer Rodewald, German Cancer Research Center, Heidelberg |
| 14:25 – 14:40 |
T11 – The bulk of the hematopoietic stem cell population is dispensable for murine steady-state and stress hematopoiesis Kristina Schödel, TU Dresden |
| 14:40 – 14:55 |
T12 – Heterogeneity and in vivo regulation of dormant hematopoietic stem cells Nina Cabezas-Wallscheid, German Cancer Research Center, Heidelberg |
| 14:55 – 15:10 |
T13 – Essential role for Setd1a-mediated histone methylation in adult hematopoietic stem cell function Kathrin Arndt, TU Dresden |
| 15:10 – 15:25 |
T14 – Biomimetic bone marrow analogs as artifical hematopoietic stem cell niches Cornelia Lee-Thedieck, Karlsruhe Institute of Technology |
| 15:25 – 15:30 |
Working group discussion |
| Lecture hall N |
Tissue engineering and organoids (Chairs: Robert Zweigerdt/Benedikt Berninger) |
| 14:00 – 14:30 |
Overview Robert Zweigerdt, Hannover Medical School Benedikt Berninger, University Medical Center, Mainz |
| 14:30 – 14:45 |
T15 – Stirred suspension culture for the scalable generation of billions of human induced pluripotent stem cells Chee Keong Kwok, University of Würzburg |
| 14:45 – 15:00 |
T16 – Biofabrication of a perfusable 3D liver tissue construct using organoids Kerstin Schneeberger, Utrecht University, Netherlands |
| 15:00 – 15:15 |
T17 – Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modeling Alexander Kleger, University Medical Center, Ulm |
| 15:15 – 15:30 |
T18 – Differentiation of pericytes from hiPSCs for the vascularization of bioartificial cardiac tissues Mónika Szepes, Hannover Medical School |
| 15:30 – 16:00 | Coffee break / Industry exhibition |
| Lecture hall H |
|
| 16:00 – 17:00 |
GSCN General membership meeting |
| 17:00 – 19:00 | Poster session I: P001 – P077 P001 – P017: Pluripotency and reprograming P018 – P039: Somatic stem cells and development P040 – P053: Hematopoietic stem cells P054 – P060: Stems cells and ageing, genome stability and epigenetics P061 – P066: Stem cells in diseases: cancer stem cells P067 – P077: Computational stem cell biology and systems biology Even numbers: please present your poster from 17:00 – 18:00 Odd numbers: 18:00 – 19:00 |
| Lecture hall F | |
| 19:00 – 19:45 |
Keynote lecture III K3 – Generation of human organs in pigs Hiroshi Nagashima, Meiji University, Tokyo, Japan (Chair: Tobias Cantz, in collaboration with ELSI project “induced totipotency”) |
| 19:45 – 21:00 | Informal GSCN Get together for all participants with dinner buffet at the foyer of the MHH |
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Tuesday, 13 September
| Concurrent scientific working group session II |
|
|
| Lecture hall H |
Stem cells in disease modeling and drug development (Chairs: Karl-Ludwig Laugwitz/Oliver Brüstle) | |
| 09:00 – 09:15 | Overview Karl-Ludwig Laugwitz, TU München |
|
| 09:15 – 09:30 | T19 – Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human embryonic stem cell-derived cardiomyocytes Natalia Weber, Hannover Medical School |
|
| 09:30 – 09:45 | T20 – A new model to study neurotoxicity of drug metabolites based on chemical conversion to neurons-on-a-chip in tandem with liver-on-a-chip Xinlai Cheng, Heidelberg University |
|
| 09:45 – 10:00 | T21 – Employing rapid phenotypic assays in SPG4 patient neurons for drug discovery and rescue Kristina Rehbach, University of Bonn |
|
| 10:00 – 10:15 | T22 – Patient-specific iPS cell-based modeling of Transthyretin-Related Familial Amyloid Polyneuropathy Jeannine Hoepfner, Hannover Medical School |
|
| 10:15 – 10:30 | Working group discussion | |
| 10:30 – 11:00 |
Coffee break/industry exhibition |
|
| Lecture hall G | Stem cells and aging, genome stability and epigenetics (Chairs: Hartmut Geiger/Karl Lenhard Rudolph) | |
| 09:00 – 09:15 | Overview Hartmut Geiger, Ulm University |
|
| 09:15 – 09:30 | T23 – Dnmt3b-dependent intragenic DNA methylation prevents RNA Polymerase II spurious entry on gene bodies and cryptic transcription initiations Francesco Neri, Leibniz Institute on Aging, Jena |
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| 09:30 – 09:45 | T24 – Aging shifts the mode and outcome of the hematopoietic stem cell division M. Carolina Florian, University of Ulm |
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| 09:45 – 10:00 | T25 – Bone marrow niche and hematopoietic stem cell differentiation are regulated by the microbiota Aline Bozec, University of Erlangen-Nuremberg |
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| 10:00 – 10:15 | T26 – Restricted regeneration of hematopoietic stem cells in vivo following chronic inflammatory stress Ruzhica Bogeska, German Cancer Reserach Center, Heidelberg |
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| 10:15 – 10:30 | T27 – Hoxa9 induced developmental signals impair stem cells and regeneration of aging muscle Simon Schwörer, Leibniz Institute on Aging, Jena |
|
| 10:30 – 11:00 |
Coffee break/industry exhibition |
|
| Lecture hall M | Computational stem cell biology and systems biology (Chairs: Georg Fuellen/Ingo Roeder) |
|
| 09:00 – 09:15 | Overview Carsten Marr, Helmholtz Center Munich |
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| 09:15 – 09:30 | T28 – Scoring cell identity from transcription profiles Nancy Mah, Berlin-Brandenburg Center for Regenerative Therapies, Charite, Berlin |
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| 09:30 – 09:45 | T29 – Understanding and predicting regulatory mechanisms in early differentiation of human pluripotent stem cells Erika Gaspari, University of Bologna, Italy |
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| 09:45 – 10:00 | T30 – FGF/MAPK signaling sets the switching threshold of a bistable circuit controling fate decisions in embryonic stem cells Christian Schröter, Max Planck Institute of Molecular Physiology, Dortmund |
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| 10:00 – 10:15 | T31 – Reconstructing lineage branching from single cell RNA-seq in adult haematopoiesis via diffusion pseudo time Maren Büttner, Helmholtz Center Munich |
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| 10:15 – 10:30 | Working group discussion | |
| 10:30 – 11:00 |
Coffee break/industry exhibition |
|
| Lecture hall N | Genome engineering and gene therapy (Chairs: Axel Schambach/ Hans Schöler) (in collaboration with ELSI project “induced totipotency”) |
|
| 09:00 – 09:15 | Overview – Germ Cell Differentiation Hans Schöler, MPI f. Molecular Biomedicine, Münster |
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| 09:15 – 09:30 | Overview – Gene Therapy & Genome Engineering Axel Schambach, Hannover Medical School |
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| 09:30 – 09:45 | T32 – Designer-nuclease mediated knockout of HIV co-receptor CCR5 – a promising gene-therapy approach to protect T cells from HIV infection Boris Fehse, UKE Hamburg |
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| 09:45 – 10:00 | T33 – Efficient introduction of homo- and heterozygous mutations with CRISPR/Cas9 and applications to disease modeling in stem cells Dominik Paquet, The Rockefeller University, New York, U.S.A. |
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| 10:00 – 10:15 | T34 – Efficient and accurate precision genome engineering of transcriptionally silent disease-related loci by CRISPR/Cas9 nickase Reto Eggenschwiler, Hannover Medical School |
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| 10:15 – 10:30 | T35 – Generation of HLA depleted human pluripotent stem cell lines for modulation of the immunogenicity of iPSC derivatives Lena Engels, Hannover Medical School |
|
| 10:30 – 11:00 |
Coffee break/industry exhibition |
|
| Industry session: “Technologies from GSCN industry partners” | |
|
| Lecture hall H |
Main supporter (Chair: Michael Cross) | |
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C1 – Simplified dopaminergic neuron and cardiac differentiation of single episome reprogrammed fibroblasts Rick I. Cohen, Rutgers University, Piscataway, U.S.A., representing PeproTech GmbH |
|
| 11:35 – 12:05 | C2 – Expansion of Human Bone Marrow-Derived Mesenchymal Stem Cells in BioBLU® 0.3c Single-Use Bioreactors Aurélie Tacheny, Eppendorf Application Technologies S.A., Namur, Belgium |
|
| 12:05 – 12:35 | C3 – A novel system to generate HPS cell-derived hepatocytes with potential application to drug discovery and metabolism, and hepatotoxicity studies Barbara Küppers-Munther, Takara Bio Europe, Gothenburg, Sweden |
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| Lecture hall G | Supporter (Chair: Dirk Strunk) | |
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C4 – Generation of dopaminergic precursor cells and terminally differentiated neurons from human pluripotent cells for drug discovery and cell therapy Mohan C Vemuri, Thermo Fisher Scientific, Frederick, U.S.A. |
|
| 11:35 – 12:05 | C5 – Enabling GMP-compliant iPSC expansion and differentiation on the CliniMACS® Prodigy platform Sebastian Knöbel, Miltenyi Biotec GmbH, Bergisch Gladbach |
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| 12:05 – 12:35 | C6 – Using Pluripotent Stem Cells in the Age of Genome Editing Theresa Dsouza, R&T Lonza Bioscience, Cologne |
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| Lecture hall M | Supporters (Chair: Michael Rieger) | |
| 11:00 – 11:05 | Introduction | |
| 11:05 – 11:35 | C7 – Translation of cell-based gene therapy into clinical application Elena Meurer, apceth GmbH & Co. KG, Munich |
|
| 11:35 – 12:05 | C8 – Simultaneous single-molecule quantification of DNA, RNAs & Proteins Maik Pruess, Nanostring Technologies, Hamburg |
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| 12:05 – 12:35 | C9 – STEMdiff™ Kits for Robust and Efficient Differentiation of Human Pluripotent Stem Cells Katharina Debowski, Stem Cell Technologies SARL, Cologne |
|
| Lecture hall N |
Satellitensymposium “Totipotente Nicht-Embryonen und nicht-totipotente Embryonen” |
|
| 11:00 – 18:15 |
open to GSCN participantsProgram (in german) |
|
| 12:35 – 14:00 | Lunch buffet/industry exhibition/poster viewing | |
| 12:45 – 13:45 | Meet-the-expert tables (Bistro/ground floor): Ingo Roeder (Bioinformatic analysis of biological data), Hans Schöler and Ana Martin-Villalba (limited to 10 registered participants each) |
|
| Lecture hall F |
Presidential Symposium (Chair: Ulrich Martin) | |
| 14:00 – 14:30 |
PS1 – Engineered human heart muscles for disease modelling and cardiac repair Thomas Eschenhagen, UKE, Hamburg |
|
| 14:30 – 15:00 | Young Investigator Award 2016 PS2 – Developmental programming by lncRNA-TF pairs during the induction of the embryonic heart Leo Kurian, University of Cologne |
|
| 15:00 – 15:30 |
Female Scientist Award 2016 PS3 – Generation and regeneration of human and murine hematopoietic stem cells Claudia Waskow, TU Dresden |
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| 15:30 – 16:00 | Publication of the Year 2016 Award (June 2015 – 2016) PS4 – Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis Guanqgi Song, Hannover Medical School |
|
| 16:00 – 16:30 |
Coffee break/industry exhibition |
|
| 16:30 – 18:30 | Poster session II: P078 – P147 P078 – P091: Tissue engineering and organoids P092 – P097: Genome engineering and gene therapy P098 – P119: Stem cells in regenerative therapies P120 – P124: Stem cells in regenerative therapies: mesenchymal stem/stroma cells P125 – P147: Stem cells in disease modeling and drug development Even numbers: please present your poster from 16:30 – 17:30 Odd numbers: 17:30 – 18:30 |
|
| 18:30 – 19:00 | Bus transfer | |
| 19:00 – 01:00 |
GSCN Networking evening for all participants with dinner buffet and DJ at the Yukon Bay, Hannover Zoo |
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Wednesday, 14 September
| Concurrent scientific working group session III | ||
| Lecture hall H |
Somatic stem cells and development (Chairs: Ana Martin Villalba/Thomas Braun) | |
| 09:00 – 09:15 | Overview Jan Lohmann, Centre of Organismal Studies, Heidelberg University |
|
| 09:15 – 09:30 | T36 – Fate-restriction precedes stemness during massive post-embryonic growth in the fish branchia Lazaro Centanin, Centre of Organismal Studies, Heidelberg University |
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| 09:30 – 09:45 | T37 – Visualization of stem cell induction and differentiation in real time Rasmus Freter, University of Oxford |
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| 09:45 – 10:00 | T38 – Embryo-derived macrophages regulate the dendritic cell pool size in the adult spleen Gulce Percin, TU Dresden |
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| 10:00 – 10:15 | T39 – A role for YAP and TAZ signaling in human neural crest development Alexandra Larisa Condurat, Freiburg University |
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| 10:15 – 10:30 | Working group discussion | |
| Lecture hall G | Stem cells in reg. therapies II (Chairs: Richard Schäfer/Dirk Strunk) | |
| 09:00 – 09:15 | Overview Karen Bieback, Medical Faculty Mannheim, Heidelberg University |
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| 09:15 – 09:30 | T40 – Stepwise maturation of human iPS cells into immunosuppressive mesenchymal stem/progenitor cells Cornelia Scharler, Paracelsus Private Medical University of Salzburg, Austria |
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| 09:30 – 09:45 | T41 – Cryopreserved or fresh mesenchymal stromal cells: only a matter of taste or key to unleash the full clinical potential of MSC therapy? Guido Moll, Charite Berlin |
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| 09:45 – 10:00 | T42 – Synthetic niche to modulate regenerative potential of mesenchymal stromal cells (MSCs) and enhance skeletal muscle regeneration Sven Geißler, Charite Berlin |
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| 10:00 – 10:15 | T43 – Extracellular vesicles – From bench to bedside Verena Börger, University Hospital Essen |
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| 10:15 – 10:30 | Working group discussion | |
| Lecture hall N |
Stem cells in diseases: cancer stem cells(Chairs: Thomas Brabletz/Andreas Trumpp) |
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| 09:00 – 09:20 | Overview Andreas Trumpp, German Center Reserach Center, Heidelberg |
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| 09:20 – 09:40 | T44 – ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types Julia Kleemann, University of Erlangen-Nuremberg |
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| 09:40 – 10:00 | T45 – Heterotrimeric G-proteins are indispensable for FLT3-ITD autophosphorylation and oncogenic function Michael Rieger, Goethe University Hospital and LOEWE Center Frankfurt |
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| 10:00 – 10:15 | T46 – A mathematical model approach to study the immunological effects in CML patients during and after TKI treatment Ingmar Glauche, TU Dresden |
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| 10:15 – 10:30 | Working group discussion | |
| 10:30 – 11:00 |
Coffee break/industry exhibition | |
| Concurrent strategic working group session |
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| Lecture hall H |
Technologies in stem cell research (Chairs: Frank Emmrich/Andreas Bosio) | |
| 11:00 – 11:25 | S1 – Intestinal epithelial organoids – an accessible model for mammalian stem cell niche biology Henner Farin, Georg-Speyer-Haus, Frankfurt |
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| 11:25 – 11:50 | S2 – 3D bioartificial cardiac tissue from pluripotent stem cells Ina Gruh, REBIRTH, Hannover Medical School |
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| 11:50 – 12:15 | S3 – Using cerebral organoids for studying human disease modeling and lineage reprogramming Marissa Karow, LMU Munich |
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| 12:15 – 12:30 | Panel discussion | |
| Lecture hall G | Career development and funding opportunities (Chairs: Insa Schröder/Hartmut Geiger) | |
| 11:05 – 11:40 | S4 – Career paths for scientists – suitable application strategies Anke Raloff, ZEIT Verlagsgruppe/ACADEMICS |
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| 11:40 – 12:15 | S5 – tba tbc |
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| 12:15 – 12:30 | Panel discussion | |
| Lecture hall N |
Clinical trials and regulatory affairs (Chairs: Torsten Tonn/Andreas Kurtz) |
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| 11:00 – 11:25 | S6 – Investigator initiated trials (IIT) of advanced therapy medicinal products Felipe Prosper, University Clinic Navarra, Pamplona, Spain |
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| 11:25 – 11:50 | S7 – EU research perspective on advanced therapies Arnd Hoeveler, European Commission, Brussels |
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| 11:50 – 12:15 | S8 – Mapping the European landscape for patenting stem cell related inventions Aliki Nichogiannopoulou, European Patent Office, Munich |
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| 12:15 – 12:30 | Panel discussion | |
| 12:30 – 14:00 |
Lunch buffet/industry exhibition/poster viewing |
|
| 12:45 – 13:45 | Meet-the-expert tables (Bistro/ground floor): Marisa Karow (Cerebral organoids), Henner Farin (Intestinal epithelial organoids) and Ina Gruh (3D bioartificial cardiac tissue) register at the registration desk (limited to 10 registered participants each) | |
| Lecture Hall F | Joined session with Rebirth/Hannover Medical School (MHH) | |
| 14:00 – 14:45 |
Keynote lecture IV K4 – Patterning mesoderm and blood development from human pluripotent stem cells Peter Zandstra, University of Toronto, Canada (Chair: Karl Lenhard Rudolph) |
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| 14:45 – 15:30 |
Keynote lecture V K5 – Stemming vision loss using stem cells – seeing is believing Pete Coffey, University College London, U.K. (Chair: Thomas Braun ) |
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| 15:30 – 15:45 | GSCN Outlook 2017 Incoming president: Karl Lenhard Rudolph |
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| 15:45 – 16:15 |
Coffee break/industry exhibition | |
| Lecture hall F | Rebirth Session (Chairs: Ulrich Martin/Tobias Cantz) | |
| 16:15 – 16:35 | RB1 – From cell to product: governance issues along the translational pathway Nils Hoppe, CELLS – Centre for Ethics and Law in the Life Sciences, Leibniz University Hannover |
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| 16:35 – 16:55 | RB2 – Emerging protein- and small molecule-based therapies for cardiac repair Kai Wollert, Hans Borst Center for Heart and Stem Cell Research, Hannover Medical School |
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| 16:55 – 17:15 | RB3 – Therapeutic noncoding RNA based approaches of heart failure Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School |
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| 17:15 – 17:35 | RB4 – Manufacturing human pluripotent stem cells and their progenies Robert Zweigerdt, Hannover Medical School |
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| Lecture hall F | Closing ceremony | |
| 17:35 – 17:50 | Poster award ceremony and announcement of industry quiz winners (Daniel Besser; GSCN) supported by PeproTech GmbH |
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| End of GSCN conference 2016 |
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| Announcement: | ||
| 19:00 – 21:00 | GSCN Public outreach event with panelists (in German) Moderne Zelltherapien – Stammzellen bei Herz- und Lebererkrankungen Podiumsdiskussion und Kurzfilme |
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| Podiumsgäste: Prof Dr. Axel Haverich, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, MHH Prof. Dr. Ulrich Martin, Leibniz Forschungs- laboratorien für Biotechnologie und künstliche Organe , MHH Prof. Dr. Michael Manns, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, MHH Prof. Dr. Nils Hoppe, Centre for Ethics and Law in the Life Sciences Hannover, LUH Moderation: Dr. Stefanie Seltmann, DKFZ Heidelberg |
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© German Stem Cell Network (GSCN) e.V., 2016
Last updated 29/01/2016, Powered by Webdesigner Berlin
Last updated 29/01/2016, Powered by Webdesigner Berlin