Program
Download the short program 
here;
and the complete program (including abstracts) will be available to participants after the conference.
The program and all the information around the conference will be available from Tuesday, 18.09.2018 for mobile devices (
Apple Store and Google Play for Android). Please follow this link or use the QR code.
| Wednesday | Thursday | Friday |
Wednesday, 19 September
| Lecture hall |
Joined Session with Behr Symposium Chairs: Andreas Trumpp / Nina Cabezas-Wallscheid |
| 09:00 – 09:25 |
T01 – Transcriptional and epigenetic control of cardiogenesis Gergana Dobreva, Medical Faculty Mannheim, Uni. Heidelberg |
| 09:25 – 09:45 | T02 – Organ topology splits homeostatic and growth stem cells in fish Lázaro Centanin, Centre for Organismal Studies (COS), Uni. Heidelberg |
| 09:45 – 10:30 | Keynote lecture I K1 – Tracking HSC self-renewal and differentiation in the niche Leonard Zon, Harvard Department of Stem Cell and Regenerative Biology, Cambridge, US |
| 10:30 – 11:00 | Coffee break / Industry exhibition / Registration |
| Lecture hall |
Opening |
| 11:00 – 11:20 | Welcome to German Cancer Research Center, Heidelberg |
| 11:20 – 11:30 | GSCN Annual Conference 2018 Ana Martin-Villaba, President GSCN |
| 11:30 – 12:15 |
Keynote lecture II K2 – Global views of development: reconstructing trajectories and lineages Alex Schier, Havard University, Cambridge, US (Chair: Lázaro Centanin) |
| 12:15 – 13:00 | Keynote lecture III K3 – Engineered human heart tissue models of inherited heart disease William Pu, Harvard Stem Cell Institute, Cambridge, US (Chair: Gergana Dobreva) |
| 13:00 – 14:30 |
Lunch break / Industry exhibition |
| 14:30 – 16:00 | Concurrent scientific working group session I |
| Lecture hall 14:30 – 15:00 15:00 – 15:12 15:12- 15:24 15:24 – 15:36 15:36 – 15:48 15:48 – 16:00 |
Technobeat workshop (Chairs: Robert Zweigerdt / Dirk Strunk) T03 – Special keynote: Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart Michael Laflamme, Toronto General Hospital Research Institute, Canada T04 – Chemically defined cardiomyogenic differentiation of human pluripotent stem cells in bioreactors Caroline Halloin, Hannover Medical School T05 – Aiming for increased retention of cardiac cell aggregates in a porcine model of myocardial infarction Evelyne Demkes, UMC Utrecht, Netherlands T06 – Development of immunosuppressive iPSC-derived stromal cells for tissue regeneration Patricia Peking, Paracelsus Medical University, Salzburg, Austria T07 – Human stem cell-derived cardiac fibroblasts enhance structural and functional cardiomyocyte maturation in a three-dimensional microtissue environment Elisa Giacomelli, Leiden University Medical Center, Netherlands T08 – The detection and minimisation of genetically variant stem cells in human pluripotent stem cell cultures Jason Halliwell, Uni. Sheffield, U.K. |
| Room I & II 14:30 – 15:00 15:00 – 15:15 15:15- 15:30 15:30 – 15:45 15:45 – 16:00 |
Computational stem cell biology (Chairs: Georg Füllen / Ingo Röder) T09 – Special keynote: Dynamics of T cell memory generation inferred from single cell fate mapping in vivo Michael Floßdorf, TU Munich T10 – Divisional behaviour of haematopoietic stem cells revisited: insights from a mathematical model of in vivo label dilution Thomas Zerjatke, TU Dresden T11 – Unidirectional and progressive DNA methylation changes define hematopoietic lineage commitment Sina Stäble, German Cancer Research Center, Heidelberg T12 – Reconstruction of haematopoetic differentiation trajectory using Triplet-network Tingying Peng, HelmholtzZentrum Munich T13 – A web application for predicting cell-fate determinants in cell differentiation Andras Hartmann, Luxembourg Center for Systems Biomedicine |
| LH Marsilius Kol. 14:30 – 15:00 15:00 – 15:15 15:15- 15:30 15:30 – 15:45 15:45 – 16:00 |
Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz / Michael Rieger) T14 – Special keynote: A molecular subtype of cancer originating from adult stem cells during regeneration is driven by Dux transcription factors Johnny Kim, MPI-HLR, Bad Nauheim T15 – Orchestration of stem- and EMT-like phenotypes during tumor initiation and progression Oguzhan Kaya, German Cancer Research Center, Heidelberg T16 – Unbiased identification of tumour suppressor function by pooled CRISPR/Cas9 screening in human colon organoids Henner Farin, Georg-Speyer-Haus, Frankfurt T17 – The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis Elisabeth Letellier, Uni. Luxembourg T18 – High Transglutaminase 2 activity is a poor prognostic marker in colorectal carcinoma and essential for cell survival and stemness Ilaria Lunger, Goethe Uni. Hospital, Frankfurt |
| 16:00 – 16:30 |
Coffee break / Industry exhibition |
| Room I & II |
|
| 16:30 – 17:30 |
GSCN General membership meeting |
| 17:30 – 19:30 | Poster session I: P001 – P069 Gallery DKFZ P001 – P009: Computational stem cell biology P010 – P014: Stem cells in diseases: cancer stem cells P015 – P029: Hematopoietic stem cells Foyer Marsilius Kolleg P030 – P069: Stem cells in regenerative therapies Even numbers: please present your poster from 17:30 – 18:30 Odd numbers: 18:30 – 19:30 |
| 19:45 – 20:30 Lecture hall |
Keynote lecture IV K4 – The blastoid: blastocyst-like structures generated solely from stem cells Nicolas Rivron, Hubrecht Institute, Utrecht, Netherlands (Chair: Tobias Cantz) |
| 20:30 – 22:00 | Informal GSCN get together for all participants with dinner buffet at the foyer |
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Thursday, 20 September
| 09:00 – 10:30 |
Concurrent scientific working group session II | |
| Lecture hall 09:00 – 09:30 09:30 – 09:45 09:45 – 10:00 10:00 – 10:15 10:15 – 10:30 |
Stem cells in disease modelling and drug development (Chairs: Oliver Brüstle / Karl-Ludwig Laugwitz) T19 – Special keynote: Pluripotent stem cell models of human heart disease Karl-Ludwig Laugwitz. TUM School of Medicine, Munich T20 – Recapitulation of plaque formation, tau pathology and neurodegeneration in a human 3D model of Alzheimer’s disease Matthias Hebisch, Institute for Reconstructive Neurobiology, Uni. Bonn T21 – Neural retina differentiation of hESCs as an in vitro model for retinoblastoma Julia Menges, Institute of Human Genetics, University Hospital Essen T22 – IndivuHeart – Risk assessment for heart diseases with patient-specific iPSC-derived engineered heart tissue Bärbel Ulmer, University Medical Center Hamburg-Eppendorf (UKE) T23 – A coherent roadmap to generate either pancreatic acinar or duct-like cells from human pluripotent stem cells challenges pancreatic cancer biology Meike Hohwieler, Internal Medicine I, Ulm University Hospital |
|
| Room I&II 09:00 – 09:30 09:30 – 09:45 09:45 – 10:00 10:00 – 10:15 10:15 – 10:30 |
Pluripotency and Re-programing (Chairs: Hans Schöler / Mathias Treier) T24 – Special keynote: Engineering a safe and allo-tolerated pluripotent stem cell line; a global source for off-the-shelf therapeutic cell products Andras Nagy, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada T25 – Reprogramming factor promiscuity requires co-factors to ensure cell fate specificity Moritz Mall, German Cancer Research Center, Heidelberg T26 – Genome-wide analyses of LINE-1 (L1) integromes in human induced pluripotent stem cells uncover insertional bias for active transcriptional start sites Gerald Schumann, Paul Ehrlich Institute, Langen T27 – Expanded potential stem cells (EPSCs) derived from porcine embryos contribute to porcine development in vivo Monika Nowak-Imialek, Hannover Medical School T28 – Identification of embryonic neural border stem cells and its generation by direct reprogramming from human blood Marc Christian Thier, German Cancer Research Center, Heidelberg |
|
| 10:30 – 11:00 |
Coffee break / Industry exhibition |
|
| 11:00 – 12:30 |
Industry session: “Technologies from GSCN industry partners” |
|
| Lecture hall 11:00 – 11:45 11:45 – 12:30 |
Main supporter (Chair: Michael Cross) C1 – Stem cell bioprocessing: process design, scale-up, and product safety Philipp Nold, Eppendorf AG C2 – Large-scale production of induced pluripotent stem cells-derived megakaryocytes in bioreactors Constanca Figueiredo, Hannover Medical School representing PeproTech GmbH |
|
| Room I&II 11:00 – 11:30 11:30 – 12:00 12:00 – 12:30 |
Supporter (Chair: Frank Edenhofer) C3 – Creation of isogenic cell lines for disease modelling, using CRISPR/CAS9 footprint-free gene editing and single-cell cloning of human iPS cells Anders Aspegren, Takara Bio Europe C4 – Translating research protocols and tools to manufacturing concepts for PSC-derived ATMPs Sebastian Knöbel, Miltenyi Biotec GmbH C5 – Removing inherent bottlenecks in the genome engineering of iPSCs to build relevant disease models for target and compound screening Jon Chesnut, Thermo Fisher Scientific |
|
| LH Marsilius Kol. 11:00 – 11:30 11:30 – 12:00 |
Supporter (Chair: Ulrich Martin) C6 – Considerations for serum-free, xeno-free media for stem cell applications Suzanne Badoux, Biological Industries (BI), Ltd. C7 – Organoids are complex, growing them shouldn’t be: Efficient, standardized tools for organoid culture Katharina Debowski, STEMCELL Technologies GmbH |
|
| 12:30 – 14:00 | Lunch break / Industry exhibition / Poster viewing | |
| 12:45 – 13:45 | Meet-the-expert tables(limited to 10 registered participants each) Gergana Dobreva, Medical Faculty Mannheim, Uni. Heidelberg; Lázaro Centanin, Centre for Organismal Studies (COS), Uni. Heidelberg |
|
| Lecture hall |
||
| 14:00 – 16:15 |
Presidential Symposium Chair: Ana Martin-Villalba |
|
| 14:00 – 14:45 |
Keynote PS1 – Human glial progenitor cell-based treatment and modeling of neurological disease Steve Goldman, University of Rochester Medical Center, US/Center for Translational Neuromedicine, Uni. Copenhagen, Denmark |
|
| 14:45 – 15:15 |
Female Scientist Award 2018 PS2 – Epigenetic mechanisms of cellular plasticity Maria Elena Torres-Padilla, Helmholtz Zentrum München, Munich |
|
| 15:15 – 15:45 |
Young Investigator Award 2018 PS3 – Regulation of dormant hematopoietic stem cells Nina Cabezas-Wallscheid, Max Planck Institute of Immunobiology and Epigenetics, Freiburg |
|
| 15:45 – 16:15 |
Publication of the Year 2018 Award PS4 – Senescence-associated reprogramming promotes cancer stemness Maja Milanovic, Charité, Berlin |
|
| 16:15 – 16:30 |
Coffee break / Industry exhibition |
|
| 16:30 – 18:30 | Poster session II: P070 – P145 DKFZ Gallery P070 – P082: Pluripotency and reprograming P083 – P096: Somatic stem cells and development Foyer Marsilius Kolleg P097 – P145: Stem cells in disease modeling and drug development Even numbers: please present your poster from 16:30 – 17:30 Odd numbers: 17:30 – 18:30 |
|
| 19:00 – 01:00 |
GSCN Networking evening for all participants with dinner buffet and DJ at the Frauenbad, Heidelberg |
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Friday, 21 September
| |
||
| 09:00 – 10:30 |
Concurrent scientific working group session III | |
| Lecture hall 09:00 – 09:30 09:30 – 09:45 09:45 – 10:00 10:00 – 10:15 10:15 – 10:30 |
Stem cells in regenerative therapies (Chairs: Ulrich Martin / Wolfgang Wagner) T29 – Special keynote: Photoreceptor transplantation into the mammalian retina Marius Ader, Center for Regenerative Therapies (CRTD), TU Dresden T30 – Thyroid hormone signaling controls zebrafish brain regeneration Michael Brand, Center for Regenerative Therapies (CRTD), TU Dresden T31 – Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring Yuval Rinkevich, HelmholtzZentrum Munich T32 – Investigation of the role of pericytes in the in vitro model of bioartificial tissue formation from hPSC-derived cardiovascular cell types Monika Szepes, Hannover Medical School T33 – Hematopoietic stem cell gene therapy for Ifngr1-deficiency highlights role of macrophages in mycobacterial infections and paves way for macrophage transplantation therapy Kathrin Haake, Hannover Medical School |
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| Room I & II 09:00 – 09:30 09:30 – 09:45 09:45 – 10:00 10:00 – 10:15 10:15 – 10:30 |
Hematopoietic stem cells (Chairs: Albrecht Müller / Claudia Waskow) T34 – Special keynote: Impact of inflammation on hematopoietic stem cells Mick Milsom, German Cancer Reserach Center, Heidelberg T35 – Cell-extrinsic and -intrinsic regulation of PU.1 in HSC lineage choice Nouraiz Ahmed, Department of Biosystems Science & Engineering, ETH Zurich/Basel, Switzerland T36 – Combined single-cell and spatial transcriptomics to deconvolute the hematopoietic and mesenchymal stem cell niche Simon Haas, German Cancer Reserach Center, Heidelberg T37 – P53 prevents malignant transformation of hematopoietic stem cells by forcing their entry into the cell cycle and apoptosis in response to DNA damage Andreas Brown, Institute for Molecular Medicine, Uni. Ulm T38 – Functional dominance of CHIP-mutated hematopoietic stem cells in patients undergoing autologous stem cell transplantations Lena Dorsheimer, University Hospital, Goethe University, Frankfurt |
|
| LH Marsilius Kol. 09:00 – 09:30 09:30 – 09:45 09:45 – 10:00 10:00 – 10:15 10:15 – 10:30 |
Somatic stem cells and development (Chairs: Thomas Braun / Federico Calegari) T39 – Special keynote: Beta cell development, heterogeneity and regeneration Heiko Lickert, Institute of Diabetes and Regeneration Research, HelmholzZentrum Munich T40 – Endoderm formation does not require a mesendoderm progenitor stage and is independent from brachyury function Silvia Engert, Institute of Diabetes and Regeneration Research, HelmholzZentrum Munich T41 – DNA methylation changes during culture expansion of mesenchymal stromal cells are strand-specific and reflect changes in chromatin conformation Julia Franzen, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen Medical School T42 – Setting the gene regulatory landscape driving astrogliogenesis by stage-specific transcription factors Neha Tiwari, Institute of Physiological Chemistry, University Medical Center, Mainz T43 – Quiescence regulates the number of neural stem cells and their regenerative capacity in the aging brain Georgios Kalamakis, German Center Research Center, Heidelberg |
|
| 10:30 – 11:00 |
Coffee break / Industry exhibition | |
| 11:00 – 12:30 | Concurrent strategic working group session | |
| Lecture hall |
Career development (Chairs: Hartmut Geiger / Insa Schröder) S1 – Mobbing at the workplace: effective solutions for livable working environments / Mobbing am Arbeitsplatz und wirksame Antworten für lebenswerte Arbeitskulturen (EN/DE) Matthias Tholen, Tholen Beratung, Heidelberg Annette Bornhäuser, Selbstcoaching, Heidelberg |
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| Room I & II 11:00 – 11:30 11:30 – 12:00 12:00 – 12:30 |
Technologies in stem cell research – Microfluidics in stem cell research (Chairs: Michael Cross / Sebastian Knöbel) S2 – Modelling human rostro-caudal neural patterning with microfluidic gradients Agnete Kirkeby, University of Copenhagen, Denmark S3 – Microfluidic ipSC-derived human autologous organ-on-chip Nicola Elvassore, University of Padova, Italy S4 – Microfluidic ipSC-derived human autologous multi-organ-chips Ousamma El-Baraka, TissUse GmbH, Berlin |
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| LH Marsilius Kol. 11:00 – 11:30 11:30 – 12:00 12:00 – 12:30 |
Clinical trials and regulatory affairs (Chairs: Andreas Kurtz / Zoltan Ivics) S5 – Pluripotent stem cell-based therapy in type-1 diabetes Henrik Semb, University of Copenhagen, Denmark S6 -Translating tissue engineered heart repair Malte Tiburcy, University Medical Center Goettingen S7 – Advanced Therapy Medicinal Products (ATMPs): What is needed for smooth transition from R&D to clinical development stage Diane Seimetz, Biopharma Excellence GmbH, Munich |
|
| 12:30 – 14:00 |
Lunch break / Industry exhibition / Poster viewing |
|
| 12:45 – 13:45 | Meet-the-expert tables (limited to 10 registered participants each) Diane Seimetz, Biopharma Excellence GmbH, Munich Andreas Trumpp, German Cancer Reserach Center (DKFZ), Heidelberg |
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| Lecture hall |
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| 14:00 – 14:45 |
Keynote lecture V K5 – Genetic and epigenetic processes controlling adult stem cell behavior Allison Bardin, Institut Curie, Paris, France (Chair: Ingrid Lohmann) |
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| 14:45 – 15:30 | Keynote lecture VI K6 – Molecular control of stem cell and developmental potency Jianlong Wang, Icahn School of Medicine at Mount Sinai, New York, US (Chair: Jan Lohmann) |
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| 15:30 – 15:50 | Poster award ceremony Daniel Besser |
|
| 15:50 – 16:00 |
Closing remarks by the incoming GSCN president Hartmut Geiger |
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| End of GSCN conference 2018 |
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| Announcement: | ||
| 18:30 – 21:00 | GSCN Public outreach event with panelists (in German) |
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© German Stem Cell Network (GSCN) e.V., 2018
Last updated 24/05/2018, Powered by Webdesigner Berlin
Last updated 24/05/2018, Powered by Webdesigner Berlin