Program

Wednesday, 23 September

Download the short program here;
and the complete program (including abstracts) here

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	Opening
11:00 – 11:15	GSCN Annual Conference 2020 Hartmut Geiger, President GSCN
11:15 – 11:30	Housekeeping remarks for the virtual 8th Annual GSCN Conference Daniel Besser, GSCN
11:30 – 12:15	Keynote lecture I K1 – Regulation of mouse skeletal muscle stem cells and niche Shahragim Tajbakhsh, Institute Pasteur, Paris, FR (Chairs: Heiko Lickert / Nina Cabezas-Wallscheid)*
12:15 – 13:00	Keynote lecture II K2 – Development and maintenance of the blood system Bertie Göttgens, University of Cambridge, UK (Chairs: Heiko Lickert / Nina Cabezas-Wallscheid)
13:00 – 14:30	Break time / Industry exhibition
13:10 – 13:30	Meet the speakers corner (Meet & Greet – Networking Spaces) Meeting room 1: Discussion with Shahragim Tajbakhsh chaired by Heiko Lickert Meeting room 2: Discussion with Bertie Göttgens chaired by Nina Cabezas-Wallscheid
	Concurrent scientific working group session I
14:30 – 16:00	Stem cells in disease modeling and drug development (Chairs: Oliver Brüstle / Bert Klebl)
14:30 – 15:00	T01 – Protein homeostasis plays a critical role in buffering RNA-binding protein phase behavior during ALS and can be rescued by drugs inducing autophagy Jared Sterneckert, CRTD/TU Dresden
15:00 – 15:15	T02/P065 – Generation and correction of mutations in human iPS cells utilizing CRISPR-mediated HDR, base editors or prime editors Katrin Neumann, TU Dresden
15:15 – 15:30	T03/P078 – Detection of deleterious on-target effects after HDR-mediated CRISPR editing Isabel Weisheit, LMU Munich
15:30 – 15:45	T04/P076 – The influence of the 9p21 CAD risk locus on vascular calcification – an iPSC model Anja Trillhaase, University Lübeck
15:45 – 16:00	T05/P081 – Extracellular components of the myelodysplastic stromal bone marrow microenvironment as potential therapeutic target Manja Wobus, University hospital Dresden
14:30 – 16:00	Somatic stem cells and development (Chairs: Thomas Braun / Ana Martin-Villalba)
14:30 – 15:00	T06 – Human intestinal organoid models reveal fundamental differences between stem cell and differentiated cells response to enteric pathogens Steeve Boulant, DKFZ, Heidelberg
15:00 – 15:15	T07/P043 – A spatially resolved single cell atlas of human gastrulation Elmir Mahammadov, Helmholtz Zentrum München
15:15 – 15:30	T08/P036 – 3D biomimetic implantation niche reveals the first interactions of the embryo and the maternal blood vessels Ivan Bedzhov, MPI f. Molecular Biomedicine, Münster
15:30 – 15:45	T09/P040 – Transcriptional regulation by TAF4a is required for chromatin organization, genome stability, and maintenance of muscle stem cells Angelina Georgieva, MPI f. Heart and Lung Research, Bad Nauheim
15:45 – 16:00	T10/P047 – The plasticity of liver epithelial cells during homeostasis, regeneration and tumor formation Tianliang Sun, Novartis Institute of Biomedical Research (NIBR), Basel, CH
14:30 – 16:00	Computational stem cell biology (Chairs: Georg Fuellen / Carsten Marr)
14:30 – 15:00	T11 – Modeling cellular state and dynamics in single cell genomics Fabian Theis, Helmholtz Zentrum, Munich
15:00 – 15:15	T12/P003 – Oct4 pioneers genomic nucleosomes in motion Jan Huertas, MPI f. Molecular Biomedicine, Münster
15:15 – 15:30	T13/P006 – Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells Christian Schröter, MPI of Molecular Physiology, Dortmund
15:30 – 15:45	T14/P002 – Revealing stem cell self-renewal strategies by clonal data: limitations and opportunities Philip Greulich, Uni. Southampton, UK
15:45 – 16:00	T15/P007 – Computational modeling reveals cell-cycle dependent kinetics of H4K20 methylation states during Xenopus embryogenesis Lea Schuh, HelmholtzZentrum München
16:00 – 16:30	Break time / Industry exhibition
16:30 – 17:30	GSCN General Membership Meeting GSCN Executive Board
17:30 – 19:30	Poster session I all poster can be viewed in the poster sessions on Wednesday and Thursday, please visit the presenters in their contact rooms Poster with even numbers will be presented 17:30 – 18:30 h on Wednesday & 16:30 – 17:30 h on Thursday Odd numbers: 18:30 – 19:30 h on Wednesday & 17:30 – 18:30 h on Thursday
19:45 – 20:30	Keynote lecture III K3 – Stem cell clinical translation refracted through COVID19 Jonathan Kimmelman, McGill University, Montreal, Canada (Chairs: Sara Gerke / Tobias Cantz)
20:40 – 21:00	Meet the speakers corner (Meet & Greet – Networking Spaces) Meeting room 1: Discussion with Jonathan Kimmelman chaired by Sara Gerke
	* The chair listed first will moderate the sessions, the chair listed second will guide the Q&A rounds after the talks.
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Thursday, 24 September

09:00 – 10:30	Concurrent scientific working group session II
09:00 – 10:30	Organoids: new models for diseases (Chairs: Alexander Kleger / Stefan Liebau)*
09:00 – 09:30	T16 – Stem cell derived organoids as tissue models in health and disease Sina Bartfeld, Julius Maximilians Universität Würzburg
09:30 – 09:45	T17/P044 – Cardioids reveal self-organizing principles of human cardiogenesis Sasha Mendjan, IMBA Vienna, AT
09:45 – 10:00	T18/P051 – Modeling glioma in human brain organoids Jay Gopalakrishnan, University Düsseldorf
10:00 – 10:15	T19/P059 – Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells Jessica Merkle, University Ulm
10:15 – 10:30	T20/P009 – Exocrine pancreas on-chip: differentiation of human induced pluripotent stem cells to pancreatic ductal-like organoids at single-cell resolution Sandra Wiedenmann, Helmholtz Zentrum München
09:00 – 10:30	Stem cells in regenerative therapies: mesenchymal stromal cells (Chairs: Richard Schäfer / Wolfgang Wagner)
09:00 – 09:30	T21 – The roles of motility and endothelial adhesion for mesenchymal stromal cell therapies efficacy Richard Schäfer, DRK-Blutspendedienst Baden-Württemberg-Hessen, Frankfurt
09:30 – 09:45	T22/P099 – Dissecting the angiogenic potential of adipose-derived mesenchymal stromal cells in diabetic retinopathy Agnese Fiori, Medical Faculty Mannheim, Heidelberg University
09:45 – 10:00	T23/P104 – Bone marrow transplantation impairs the regenerative capacity of the niche Christina Schreck, TU Munich
10:00 – 10:15	T24/P102 – Hypoxia conditioned mesenchymal stem cell-derived extracellular vesicles induce increased in vitro vascular tube formation Ciarra Almeria, BOKU Vienna, AT
10:15 – 10:30	T25/P106 – The vascular nature of lung resident mesenchymal stem cells Jennifer Steens, University Hospital Essen
09:00 – 10:30	Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz / Andreas Trumpp)
09:00 – 09:30	T26 – Cancer stem cell plasticity: from cell of origin to colon cancer progression Rene Jackstadt, HI-STEM Heidelberg
09:30 – 09:45	T27/P052 – Inducible expression of KLF4 eradicates patients’ B-cell leukemia stem cells in vivo Irmela Jeremias, Helmholtz Zentrum München
09:45 – 10:00	T28/P049 – Genome-wide cooperation of the EMT-transcription factor ZEB1 with YAP and AP-1 in aggressive breast cancer types Nora Feldker, FAU University Nürnberg-Erlangen
10:00 – 10:15	T29/P053 – IREB2 protein is important for the iron level control in acute myeloid leukemia Anastasia Parmon, Goethe University, Frankfurt
10:15 – 10:30	T30/P050 – Identification of molecular and functional roles of leukemic stem cells that drive DNMT3A mutant AMLs with distinct clinical outcomes Elisa Donato, HI-STEM/DKFZ, Heidelberg
10:30 – 11:00	Break time / Industry exhibition
11:00 – 12:30	Industry session: "Technologies from GSCN industry partners"
11:00 – 12:30	Gold supporter (Chairs: Federico Calegari / Elvira Mass)
11:00 – 11:30	C01 – Stem cell derived exosome production in stirred-tank bioreactors Philipp Nold, Bioprocess Center, Eppendorf AG
11:30 – 12:00	C02 – Isolate them, expand them and use them to treat life threatening conditions: the story of MSCs and NutriStem Oren Ben-Yosef, Biological Industries
12:00 – 12:30	C03 – Multiomics single cell and spatial gene expression analysis using 10x Genomics solution Hannes Arnold, 10x Genomics
11:00 – 12:30	Silver Supporter I (Chairs: Michael Rieger / Michael Cross)
11:00 – 11:30	C04 – Spot on: pluripotent stem cell differentiation… and translation Sebastian Knöbel, Miltenyi Biotec B.V. & Co. KG
11:30 – 12:00	C05/P071 – Advance disease modeling and drug discovery using novel hiPSC-derived hepatocytes and intestinal epithelial cells Malathi Raman, Takara Bio Europe
12:00 – 12:30	C06/P109 – CERO 3D Incubator and Bioreactor – a showcase of different successful approaches improving 3D cell models Amir Keric, OLS OMNI Life Science
11:00 – 12:30	Silver Supporter II (Chairs: Marieke Essers / Claudia Waskow)
11:00 – 11:30	C07 – Advanced tools for genome engineering in iPSCs Louise Baskin, Product Management / R&D, Thermo Fisher Scientific, Carlsbad, CA
11:30 – 12:00	C08 – DURA innovations dry reagent technology for rigor in phenotypic characterization of human mesenchymal and hematopoietic stem cells Michael Kapinsky, Flow Cytometry, Beckman Coulter Life Sciences
12:00 – 12:30	C09 – PSC-derived human microglia are useful for modeling neuroinflammation and neurodegenerative disease Erin Knock, Research and Development, Stem Cell Technologies
11:00 – 12:30	Bronze Supporter (Chairs: Andreas Kurtz / Mina Gouti)
11:00 – 11:15	C10 – Assessing sarcomere microdomain destabilization with iPSC-derived cardiomyocytes from dilated cardiomyopathy patients and CRISPR/Cas9 engineered isogenic controls Antje Ebert, Göttingen University representing Peprotech GmbH
11:15 – 11:30	C11 – Satellite-like cells: reliable production, characterization and disease modeling using controlled media and conditions Alex Kiselyov, Myocea, Inc. representing Amsbio Biotechnology
11:30 – 11:45	C12 – Efficient and automated single-cell cloning of human induced pluripotent stem cells in GRIDs Katia Mattis, iota Sciences Ltd.
11:45 – 12:00	C13 – New defined serum-free and chemically defined media for mesenchymal stem cells Peter Frost, PELOBiotech GmbH
12:00 – 12:15	C14 – VectorBuilder – your one-stop shop for custom cloning and virus packaging services Matthew Wheeler, VectorBuilder GmbH
12:15 – 12:30	C15 – How live cell imaging can improve your stem cell culture; an introduction to the CytoSMART Lux2 Lieke Stemkens, R&D, CytoSMART Technologies
12:30 – 14:00	Break time / Industry exhibition
12:40 – 14:00	ELSA Symposium (Chairs: Tobias Cantz / Sara Gerke)
12:40 – 12:45	Introduction Tobias Cantz
12:45 – 13:15	Data privacy in personalized (regenerative) medicine Fruzsina Molnar-Gabor
13:15 – 13:45	Human germline editing in the era of CRISPR-Cas: risk and uncertainty, intergenerational responsibility, therapeutic legitimacy Sebastian Schleidgen
13:45 – 14:00	General Discussion chaired by Sara Gerke
13:00 – 13:45	Meet-the-expert tables (limited to 10 participants, please inform the GSCN Central Office when you are intersted to particpate in one of the three tables) Meritxell Huch Nina Cabezas-Wallscheid Ulrich Martin
14:00 – 16:15	Presidential Symposium Chairs: Hartmut Geiger / Claudia Waskow
14:00 – 14:45	Presidential Invite PS1 – Liver and pancreas organoids; their application to the study of tissue regeneration and disease Meritxell Huch, MPI-CBG, Dresden
14:45 – 15:15	GSCN 2020 Young Investigator Award PS2 – Human cerebral organoid development through the lens of single-cell genomics Barbara Treutlein, MPI for Evolutionary Anthropology, Leipzig & ETH Zürich, D-BSSE, Basel, CH
15:15 – 15:45	GSCN 2020 Female Scientist Award PS3 – The importance of gene dosage in development and disease: unravelling the epigenetic process of X-chromosome inactivation in females Edith Heard, EMBL, Heidelberg
15:45 – 16:15	GSCN Publication of the Year 2019/20 Award PS4 – Excluding Oct4 from Yamanaka cocktail unleashes the developmental potential of iPSCs Sergiy Velychko, MPI f. Molecular Biomedicine, Münster
16:15 – 16:30	Break Time / Industry exhibition
16:30 – 18:30	Poster session all poster can be viewed in both poster sessions, please visit the presenters in their contact rooms Poster with even numbers will be presented 17:30 – 18:30 h on Wednesday & 16:30 – 17:30 h on Thursday Odd numbers: 18:30 – 19:30 h on Wednesday & 17:30 – 18:30 h on Thursday
	* The chair listed first will moderate the sessions, the chair listed second will guide the Q&A rounds after the talks.
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Friday, 25 September

09:00 – 10:30	Concurrent scientific working group session III
09:00 – 10:30	Pluripotency and reprograming (Chairs: Hans Schöler / Mathias Treier)*
09:00 – 09:30	T31 – In vitro capture and characterization of embryonic rosette-stage pluripotency, a novel naive-primed pluripotency intermediate with a unique epigenome Derk ten Berge, Erasmus MC Rotterdam, NL
09:30 – 09:45	T32/P028 – Combining whole genome sequencing and retrotransposon capture-sequencing uncovered mobilization of endogenous L1, AluY and SVA_F elements in reprogrammed human keratinocytes Caroline Küstermann, Paul Ehrlich Institute, Langen
09:45 – 10:00	T33/P029 – Progressive spatial self-organization of pluripotent stem cell in colonies and aggregates Mohamed Hamdy Elsafi Mabrouk, University Hospital Aachen
10:00 – 10:15	T34/P030 – Programming human pluripotent stem cells into microglia – a novel in vitro model of neuroinflammation and neurodegneration Matthias Pawlowski, University Hospital Münster
10:15 – 10:30	T35/P023 – Direct conversion of human microglia into induced neural stem cells: a new avenue for neuroregeneration? Lea Jessica Flitsch, University Bonn
09:00 – 10:30	Stem cells in regenerative therapies (Chairs: Ulrich Martin / Michael Cross)
09:00 – 09:30	T36 – Strategies for first iPSC trials: immunology, GMP-grade manufacturing and preclinical studies Micha Drukker, HelmholtzZentrum, München
09:30 – 09:45	T37/P084 – Reconditioning the neurogenic niche of adult non – human primates by antisense oligonucleotide-mediated attenuation of TGFβ signaling Ulrich Bogdahn, University Regensburg, Velvio GmbH
09:45 – 10:00	T38/P088 – Formation of large muscle grafts and substantial improvement of heart function after injection of hiPSC-cardiomyocytes in a primate model of myocardial infarctio Ina Gruh, Hannover Medical School (MHH)
10:00 – 10:15	T39/P090 – High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling Felix Manstein, Hannover Medical School (MHH)
10:15 – 10:30	T40/P094 – Influence of cerebrospinal fluid on olfactory stem cells: prerequisite for cell therapy after spinal cord injury Markus Rövekamp, Ruhr Unversity Bochum
09:00 – 10:30	Hematopoietic stem cells (Chairs: Timm Schroeder / Claudia Waskow)
09:00 – 09:30	T41 – Stem cell based heterogeneity of interferon signaling in the hematopoietic system Marieke Essers, HI-STEM, Heidelberg
09:30 – 09:45	T42/P013 – Niche SFRP1 regulates repopulating activity of hematopoietic stem cells via PP2A-mediated regulation of CTNNB1/EP300 Franziska Hettler, TU München
09:45 – 10:00	T43/P016 – Influenza virus infection alters hematopoietic stem cells and induces emergency megakaryopoiesis Marcel Rommel, Paul Ehrlich Institute, Langen
10:00 – 10:15	T44/P014 – Asymmetric cell division modulates human hematopoietic stem cell fates Dirk Loeffler, ETH Zürich, D-BSSE Basel, CH
10:15 – 10:30	T45/P020 – Glucose metabolism in hematopoietic stem cells: less is more Mona Vogel, Unversity Ulm
10:30 – 11:00	Break Time / Industry exhibition
11:00 – 12:30	Concurrent scientific working group session
11:00 – 12:30	Clinical trials and regulatory affairs (Chairs: Zoltan Ivics / Andreas Kurtz)
11:00 – 11:45	S1 – Mesenchymal stromal cell therapy for the treatment of steroid refractory GVHD and severe COVID-19 disease? Peter Bader, University Hospital Frankfurt
11:45 – 12:30	S2 – Engineering solutions for human pluripotent stem cells differentiation: from organoid derivation to disease modeling applications. Nuria Montserrat, IBEC, Barcelona, ES
11:00 – 12:30	Career development (Chairs: Marieke Essers / Insa Schroeder)
11:00 – 11:45	S3 -Studieren in Zeiten von Corona – Herausforderungen und Lösungen Studying in times of Corona – challenges and solutions Silvia Fassbender, TU Darmstadt
11:45 – 12:30	S4 – Corona – how to boast your motivation and reduce your stress NOW Daniel Hunold, University Greifswald
11:00 – 12:30	Technologies in stem cell research (Chairs: Andreas Bosio / Sebastian Diecke)
11:00 – 11:30	S5 – Single-cell and spatial multi-omics approaches of the bone marrow Simon Haas, DKFZ, Heidelberg
11:30 – 12:00	S6 – Spatial transcriptomics: recent advances and how to solve puzzles Nikolaos Karaiskos, Max Delbrück Center/BIMSB, Berlin
12:00 – 12:30	S7- High resolution anatomical mapping of gene expression using targeted in situ sequencing Mats Nilsson, Stockholm University, SE
12:30 – 14:00	Break Time / Industry exhibition
13:15 – 14:00	Point of discussion: Sars-CoV-2 / COVID-19 and approaches with stem cells Brief introduction to the topic: Christine Mummery, Leiden, NL (Chairs: Ira Herrmann / Richard Schäfer)
15:15 – 16:00	Keynote lecture IV K4 – Cardiovascular diseases and drugs: where are we with hiPSC models? Christine Mummery, Leiden University Medical Center, NL (Chair: Alexander Kleger / Stefan Liebau)
16:00 – 16:45	Keynote lecture V K5 – Next generation cell therapies for the brain Marius Wernig, Stanford University, US (Chair: Alexander Kleger / Stefan Liebau)
16:45 – 17:05	Poster award ceremony Daniel Besser
17:05 – 17:15	Closing remarks by the incoming GSCN president Hans Schöler
17:25 – 17:45	Meet the speakers corner (Meet & Greet – Networking Spaces) Meeting room 1: Discussion with Christine Mummery chaired by Alexander Kleger Meeting room 2: Discussion with Marius Wernig chaired by Stefan Liebau
	End of GSCN Annual Conference 2020
	* The chair listed first will moderate the sessions, the chair listed second will guide the Q&A rounds after the talks.
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