Program

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the complete program (including abstracts) can be downloaded here.
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Wednesday

Thursday

Friday

Wednesday, 25 September 2024

11:00 – 11:30 H1	Opening GSCN Conference 2024
11:00 – 11:08	Welcome to Jena University Lars-Oliver Klotz, Dean of the Faculty of Biological Sciences, Friedrich-Schiller University, Jena
11:08 – 11:16	Welcome by the Medical Faculty Thomas Kamradt, Scientific Director and Dean of the Faculty of Medicine, University Hospital Jena
11:16 – 11:24	Welcome to Jena Science Campus Dario Valenzano, Scientific Director, Leibniz Institute on Aging/FLI
11:24 – 11:30	Opening of GSCN Conference 2024 Claudia Waskow, President GSCN
11:30 – 12:15	Keynote lecture I K1 – Building stem cell models for women's health research Amander Clark, Broad Stem Cell Research Center, UCLA, Los Angeles, US Chair: Florian Heidel
12:15 – 13:00	Keynote lecture II K2 – Towards reconstituting human & non-human primate axial development in vitro Cantas Alev, ASHBi Kyoto University, JP Chair: Sina Bartfeld
13:00 – 14:30	Lunch break / Industry exhibition
14:30 – 16:00	Concurrent scientific working group session I
14:30 – 16:00 H1	Stem cell organoids supported by Getinge (Chairs: Sina Bartfeld & Mina Gouti)
14:30 – 15:00	T01 – Infection and host cell tropism in the gut – organoids as model Sina Bartfeld, TU Berlin
15:00 – 15:15	T02/P – Human liver ductal cell heterogeneity and cell-state transitions in an organoid system Javier Bregante Boixg, MPI-CBG Dresden
15:15 – 15:30	T03 – P53 activation in epithelial cells terminates the fetal-like regenerative state after colitis-associated injury Kimberly Hartl, Charité Berlin
15:30 – 15:45	T04 – Cell type-specific epigenome profiling identifies H3K27me3 dynamics in the human developing neocortex Mareike Albert, CRTD, TU Dresden
15:45 – 16:00	T05 – Assessing the impact of prenatal paracetamol exposure on early human forebrain development using cerebral organoids Clara Hayn, University of Bonn
14:30 – 16:00 H2	Stem cells in aging & diseases (Chairs: Michael Rieger & Andreas Trumpp))
14:30 – 15:00	T06 – The role of leukemic stem cells in patients treated with the BCL-2 inhibitor venetoclax Andreas Trumpp, Heidelberg Institute for Stem Cell Technology HI-STEM
15:00 – 15:15	T07 – High fat diet impacts intestinal stem cell niche and causes hyperproliferation in the pig intestinal epithelium Falk Farkas, Helmholtz Center Munich
15:15 – 15:30	T08 – Relevance of dormant cancer stem cells in disease propagation and therapy resistance in JAK2V617F-driven myeloproliferative neoplasms Ian Ghezzi, DKFZ Heidelberg
15:30 – 15:45	T09 – Targeting SRSF2 mutations in leukemia with RKI-1447: a method to disrupt HSC division and alter nuclear formation Natalie Kaushansky, Weizman Institute, Rehovot, IL
15:45 – 16:00	T10 – The inflammatory connection: insights from spatial mapping of human hematopoiesis in aging and blood malignancies Borhane Guezguez, University of Mainz
14:30 – 16:00 H3	Computational stem cell biology (Chairs: Ingmar Glauche & Carsten Marr)
14:30 – 15:00	T11 – Hematopoiesis by the numbers: advances in cellular barcoding and counting cell division Leila Perié, Curie Institute, Paris, FR
15:00 – 15:15	T12/P – A scalable computational framework for annotation-independent combinatorial target identification in scRNA-seq databases Maximilian Buser, Helmholtz Center Munich
15:15 – 15:30	T13 – Tracking bone marrow regeneration after CAR-T cell therapy in myeloma at spatial single-cell resolution Jennifer Wing Lam Cheung, University Würzburg
15:30 – 15:45	T14 – Inferring the clonal dynamics of development from holistic barcoding: theory and application to tissue macrophages Maurice Langhinrichs, DKFZ Heidelberg
15:45 – 16:00	T15/P – Unveiling the mechanisms of macrophage-mediated cytokine release syndrome in CAR-T cell therapy with mathematical modeling Artur César Fassoni, TU Dresden
16:00 – 16:30	Break time / Industry exhibition
16:30 – 17:30 H3	General Meeting Executive Board & Managing Director Claudia Waskow, Hans Schöler, Heiko Lickert, Michael Cross, Andreas Trumpp, Daniel Besser
17:30 – 19:30 Foyer + H 6 (1st floor)	Poster session I (Poster number P001 – P064) (with beverages) supported by PeptiGrowth Disease modeling & drug development: P001 – P038 Hematopoietic stem cells: P039 – P054 Pluripotency & reprograming: P054 – P064 Even numbers: 17:30 – 18:30 Odd numbers: 18:30 – 19:30
19:45 -20:30 H1	Keynote lecture III (on ELSA topics) K3 – Consciousness as an ethical issue in neural organoid research Garðar Ágúst Árnason, University of Akureyri, IS Chair: Tobias Cantz
20:30 – 22:00 Mensa Philosophenweg	GSCN Get-together for all participants Dinner buffet at the Mensa Philosophenweg 20 (10-minute walk from the Friedrich Schiller University)
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Thursday, 26 September 2024

09:00 – 10:30	Concurrent scientific working group session II
09:00 – 10:30 H1	Pluripotency, somatic stem cells & development (Chairs: Thomas Braun & Hans Schöler)
09:00 – 09:30	T16 – Capture of human axial stem cells Micha Drukker, Stem Cell Technology for Microphysiological Modeling, Leiden University, NL
09:30 – 09:45	T17 – The homeobox transcription factor DUXBL controls toti- to pluripotent transition Felipe Lüttmann, TRON Mainz
09:45 – 10:00	T18 – SOX and POU transcription factors are older than stem cells and animals Ralf Jauch, University of Hong Kong, HK
10:00 – 10:15	T19/P – Lifelong persistence of nuclear RNAs in the rodent brain Sara Zocher, DZNE Dresden
10:15 – 10:30	T20 – Epithelial-stromal communication via BMP signaling is a critical regulator of site specificity in the mouse oral mucosa Kai Kretzschmar, Uni Würzburg
09:00 – 10:30 H2	HEAL Symposium (Chairs: Ulrich Martin & Robert Zweigerdt)
09:00 – 09:30	T21 – Advancing cardiac therapeutics from animals to patients Eldad Tzahor, Weizmann Institute of Science, Rehovot, IL
09:30 – 09:45	T22 – Lineage-specific cancer-related mutations in human pluripotent and adult stem cells Jonathan Jung, Hebrew University of Israel, Jerusalem, IL
09:45 – 10:00	T23 – HLA-homozygous GMP iPSCs show efficient cardiac induction on a new differentiation platform featuring scalability and enhanced robustness Soraia Martins, Catalent, Langenfeld
10:00 – 10:15	T24 – hPSC-cardiomyocyte production: standardization and protein-free upscaling to 2000 mL Niels Kriedemann, MH Hannover
10:15 – 10:30	T25/P – Optimization of cardiomyocyte cryopreservation and quality control aspects for potency and residual iPSC contaminations Fabienne Becker, University Düsseldorf
09:00 – 10:30 SR114	ELSA symposium: (Chairs: Stefan Hoffmann & Tobias Cantz) Panelists: Garðar Ágúst Árnason & others
10:30 – 11:00	Break time / Industry exhibition
11:00 – 12:30	Industry session: "Technologies from GSCN industry partners"
11:00 – 12:30 H1	Supporter I (Chair: Helen Morrison / Harald Stachelscheid)
11:00 – 11:15	C01 – Assay-ready human microglia for automated image-based phenotypic subgrouping and targeted compound screening Michael Peitz, LIFE & BRAIN GmbH (Bronze Supporter)
11:15 – 11:30	C02 – Advancing stem cell research with automated detection and isolation of stem cells and colonies Jurij Kintz, Sartorius Stedim Biotech GmbH (Bronze Supporter)
11:30 -12:00	C03 – Improved genetic stability of human pluripotent stem cell cultures passaged as single cells using eTeSR™ Adam Hirst, STEMCELL Technologies UK Ltd. (Gold Supporter)
12:00 – 12:20	C04 – Harnessing CRISPR-ready human iPSC derived cells for disease modeling and drug discovery in neurodegenerative diseases Rebecca Northeast, bit.bio (Silver Supporter)
11:00 – 12:30 H2	Supporter II (Chair: Hartmut Geiger / Anne Grapin-Botton)
11:00 – 11:15	C05 – Take your research translational the easy way: streamline your cell culture with our ready-to-use products and automated solutions Volker Arps, Bio-Techne (Bronze Supporter)
11:15 – 11:35	C06 – Bioreactor systems \| cell & gene therapy applications \| state-of-the-art Sascha Gandert, Getinge (Silver Supporter)
11:35 – 11:55	C07 – NK cell generation from iPSC suspension cultures Sara Pérez Muñoz, Thermo Fisher Scientific (Silver Supporter)
11:55 – 12:15	C08 – From R&D to manufacturing: the cell as a product Philipp Nold, Eppendorf SE (Silver Supporter)
12:15 -12:30	C09 – Innovative synthetic peptide-based growth factor : overcoming challenges in stem cell medicine production Robert Brownlee, PeptiGrowth (Bronze Supporter)
12:30 – 14:00	Lunch break / Industry exhibition supported by LIFE & BRAIN
14:00 – 16:15 H1	Presidential Symposium Chair: Claudia Waskow
14:00 – 14:45	Presidential Invite PS1 – Deconvolution of stem and progenitor cell fates and immune lineages by polylox barcoding Hans-Reimer Rodewald, German Cancer Research Center (DKFZ), Heidelberg
14:45 – 15:15	GSCN 2024 Young Investigator Award PS2 – Fetal-maternal interface across species Claudia Gerri, MPI-CBG Dresden
15:15 – 15:45	GSCN 2024 Hilde Mangold Award PS3 – Building the next generation of neuromuscular models to study disease Mina Gouti, MDC Berlin
15:45 – 16:15	GSCN Publication of the Year 2023 – 2024 Award PS4 – A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals Jorge Lázaro, TU Dresden & EMBL Barcelona, ES
16:15 – 16:30	Break time / Industry exhibition
16:30 – 18:30 Foyer + H 6 (1st floor)	Poster session II (Poster number P065 – P126) (with beverages) supported by bio-techne Stem cells in aging & disease: P065 – P077 Computational stem cell biology & sytems biology: P078 – P082 Stem cell organoids: P083 – P105 Stem cells in regenerative therapies: P106 – P121 Somatic stem cells & development: P122 – P126 Late Poster: PX01 – PX03 Even numbers: 16:30 – 17:30 Odd number: 17:30 – 18:30
19:00 – 01:00	GSCN networking event for all participants supported by STEMCELL Technologies The entrance fee is collected on site Event location: ➚ Volksbad Jena Knebelstraße 10, 07743 Jena

Friday, 27 September 2024

09:00 – 10:30	Concurrent scientific working group session III
09:00 – 10:30 H1	Stem cell in disease modeling & drug development supported by bit.bio (Chairs: Oliver Brüstle & Karl-Ludwig Laugwitz)
09:00 – 09:30	T26 – iPSCs in drug discovery – from a user’s and a personal perspective Bert Klebl, Lead Discovery Center (LDC), Dortmund
09:30 – 09:45	T27 – Patient-specific iPSC-derived hepatic organoids as model for drug dosing and mRNA-based gene therapy Malte Sgodda, Hannover Medical School (MHH)
09:45 – 10:00	T28 – Human multi-tissue organoids as an advanced teratogenicity model Liam Wilson, Hannover Medical School (MHH)
10:00 – 10:15	T29 – Cellular metabolism senses exogenous fatty acids to reprogram dormant tumour cells into aggressive oncogenic cell states Patricia Inacio, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
10:15 – 10:30	T30 – iPSC modeling of bipolar disorder 1 based on polygenic risk scores Tamara Krutenko, University of Bonn
09:00 – 10:30 H2	Hematopoietic stem cells (Chairs: Marieke Essers & Mick Milsom)
09:00 – 09:30	T31 – The bonemarrow niche under stress Marieke Essers, DKFZ & HI-Stem, Heidelberg
09:30 – 09:45	T32 – Apelin signaling restricts the formation of the blood stem cell-forming hemogenic endothelium Jean Eberlein, University of Marburg
09:45 – 10:00	T33/P – Intrinsic reconstitution potential of developmentally restricted hematopoietic stem cells in non-conditioned immunocompromised mice Marcel G.E. Rommel, UC Santa Cruz
10:00 – 10:15	T34 – Metabolic atlas of human bone marrow hematopoietic stem cells upon differentiation, aging and leukemia Maria Eleni Lalioti, MPI-IE, Freiburg
10:15 – 10:30	T35 – The function of PD-L2 expression on human hematopoietic stem cells in allogeneic immune regulation at single cell resolution Tessa Schmachtel, University Hospital Frankfurt
09:00 – 10:30 H3	Stem cells in regenerative therapies supported by Eppendorf SE (Chairs: Michael Cross & Ulrich Martin)
09:00 – 09:30	T36 – Tracking of early cell fate decisions of iPSCs based on DNA methylation Wolfgang Wagner, RWTH Aachen
09:30 – 09:45	T37 – Pooled mesenchymal stromal cells fail to represent average donor cell characteristics Janina Burk, vetmeduni, Vienna, AT
09:45 – 10:00	T38/P – Humanized osteoclasts: an interspecies chimeric immune cell Gülce Percin, Leibniz Institute on Aging/FLI, Jena
10:00 – 10:15	T39 – Resolving human alpha versus beta cell fate allocation for the generation of stem cell-derived islets Corinna Cozzitorto, Helmholtz Center Munich
10:15 – 10:30	T40 – Generation of designer stem cell-derived islets (SC-islets) to improve safety and efficacy of SC-based islet replacement therapy Eunike Setyono, Helmholtz Center Munich
10:30 – 11:00	Break time / Industry exhibition
11:00 – 12:30	Concurrent strategic working group session
11:00 – 12:30 H1	Clinical trials & regulatory affairs (Chairs: Zoltán Ivics & Andreas Kurtz)
11:00 – 11:30	S1 – Exploring public and government funding opportunities Bettina Otto, Berlin Institute of Health (BIH)
11:30 – 12:00	S2 – High-Tech Gründerfonds – early stage seed investments Christian Kannemeier, High-Tech Gründerfonds, Berlin
12:00 – 12:30	S3 – The National Office for Gene- and Cell Therapies (GCT): updates on activities and future impact Elke Luger, GCT National Network Orrice, Berlin
11:00 – 12:30 H2	Career development (Chairs: Marieke Essers & Insa Schroeder)
	S4 – Publish or perish – feed back from a journal editor Achim Breiling, EMBO Reports, Heidelberg
11:00 – 12:30 H3	Technologies in stem cell research (Chairs: Sebastian Diecke & Sebastian Knöbel)
11:00 – 11:30	S5 – Cellular microenvironments fabricated with fluid walls for disease modeling Edmond Walsh, University of Oxford, UK
11:30 – 12:00	S6 – Combining stem cell and device engineering for in vitro models of human physiology Anna Herland, KTH Royal Institute of Technology, Solna, SE
12:00 – 12:30	S7 – Stem cell-derived vessels-on-chip for cardiovascular disease modeling Matthias Meier, Helmholtz Center Munich
12:30 – 14:00	Lunch break / Industry exhibition supported by Sartorius
14:00 – 14:45 H1	Keynote lecture IV K4 – Colorful aging? an aging-specific platelet differentiation path from hematopoietic stem cells Camilla Forsberg, UC Santa Cruz, US Chair: Meritxell Huch
14:45 – 15:30 H1	Keynote lecture V K5 – Bat induced pluripotent stem cells as a model for viral tolerance and immunity Thomas Zwaka, Icahn School of Medicine at Mount Sinai, New York, US Chair: Heiko Lickert
15:30 – 15:50 H1	Poster award ceremony Daniel Besser Poster awards supported by Thermo Fisher Scientific Travel awards
15:50 – 16:00 H1	Closing remarks by the GSCN president Heiko Lickert
	End of GSCN Conference 2024
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