Program

Download the short program here;
the complete program (including abstracts) is available for participants on 📧 demand.
The program is also available as an → Online App at the start of the GSCN conference. supported by Life & Brain GmbH

Wednesday

Thursday

Friday

Wednesday, 13 September 2023

11:00 – 11:30 H 4/5	Opening GSCN Conference 2023
11:00 – 11:10	Welcome to Ulm University Thomas Wirth, Dean of the Medical Faculty of the University of Ulm
11:10 – 11:20	Welcome to the city of Ulm Hartmut Geiger, Local Organizer and Former President GSCN 2019 – 2020
11:20 – 11:30	Opening of GSCN Conference 2023 Claudia Waskow, President GSCN
11:30 – 12:15 H 4/5	Keynote lecture I K1 – Mechanisms driving clonal hematopoiesis Margaret Goodell, Baylor College of Medicine, Houston, Texas, US Chair: Claudia Waskow
12:15 – 13:00 H 4/5	Keynote lecture II K2 – Stem cell niches and beyond Hiromitsu Nakauchi, Stanford Medicine, California, US Chair: Alexander Kleger
13:00 – 14:30	Lunch break / Industry exhibition supported by denovoMatrix GmbH
14:30 – 16:00	Concurrent scientific working group session I
14:30 – 16:00 H 1	Stem cells in disease modeling & drug development I supported by bit.bio (Chairs: Oliver Brüstle / Karl-Ludwig Laugwitz)
14:30 – 15:00	T01 – Quality-controlled and well-characterized human pluripotent stem cells: a foundation for reproducible disease modeling and drug screening Harald Stachelscheid, Berlin Institute of Health (BIH) at Charité
15:00 – 15:15	T02 – RB1-negative organoids model retinoblastoma with proliferation of cone photoreceptors and loss of retinal cell type differentiation Julia Wöstefeld, University hospital Essen
15:15 – 15:30	T03 – Investigating the impact of ELP1 predisposition on SHH-medulloblastoma tumorigenesis: insights from iPSC-derived models Frederik Manz, Hopp Chidrens's Cancer Center (KiTZ) Heidelberg
15:30 – 15:45	T04 – Primary ciliary dyskinesia patient-specific hiPSC-derived airway epithelium in air-liquid interface culture recapitulates disease specific phenotypes in vitro Laura von Schledorn, Hannover Medical School (MHH)
15:45 – 16:00	T05 – Unraveling the role of long non-coding RNAs in pancreatic development and ß-cell functionality Sarah Merz, Ulm University
14:30 – 16:00 H 2	Pluripotency & reprograming supported by Miltenyi Biotec B.V.& Co. KG (Chairs: Micha Drukker / Hans Schöler)
14:30 – 15:00	T06 – Reprogramming toward next-generation stem cell models with re-engineered transcription factors Ralf Jauch, University of Hong Kong, China
15:00 – 15:15	T07 – Single cell mass cytometry analysis identifies Nacc1, a known pluripotent stem cell regulator to also regulate totipotent stem cell fate of embryonic stem cells Thulaj Mehawarde, Montreal Clinical Research Institute, Canada
15:15 – 15:30	T08 – Highly cooperative chimeric super-SOX induces naïve pluripotency across species Caitlin McCarthy, MPI for Molecular Biomedicine, Münster
15:30 – 15:45	T09 – Zic3 and Otx2 link Xist activation to the formative pluripotency network Till Schwaemle, MPI for Molecular Genetics, Berlin
15:45 – 16:00	T10 – Reprogramming activates those 55 specific polymorphic, functional LINE-1 loci in pluripotent stem cell genomes that are mobilized in human tumor cells Gerald Schumann, Paul Ehrlich Institute, Langen
14:30 – 16:00 H 3	Computational stem cell biology (Chairs: Ingmar Glauche / Carsten Marr)
14:30 – 15:00	T11 – Cell fate patterns in preimplantation mouse embryos Sabine Fischer, University of Würzburg
15:00 – 15:15	T12 – Challenges in machine-learning based detection of measurable residual disease in acute myeloid leukemia Friedemann Uscher, Technical University Dresden
15:15 – 15:30	T13 – Shedding light on spatial changes of the septin network within LT-HSCs upon aging with open-source software CellDetail Tanja Schuster, Ulm University
15:30 – 15:45	T14 – Developmental trajectories of adult B-cell Acute Lymphoblastic Leukemia (BCP-ALL)-initiating cells at a single-cell level Adrien Jolly, Goethe University Hospital, Frankfurt
15:45 – 16:00	T15 – Gene expression noise dynamics unveil functional heterogeneity of ageing hematopoietic stem cells Reyna Edith Rosales Alvarez, University of Würzburg
16:00 – 16:30	Break time / Industry exhibition supported by Thermo Fisher Scientific
16:30 – 17:30 H 2	General Meeting Executive Board & Managing Director Claudia Waskow, Hans Schöler, Heiko Lickert, Michael Cross, Andreas Trumpp, Daniel Besser
17:30 – 19:30 Foyer	Poster session I (Poster number P001-P061) supported by OLS OMNI Life Science GmbH (with beverages) Somatic stem cells & development: P001 – P008 Stem cell organoids: P009 – P017 Disease modeling & drug development: P018 – P061 Even numbers: 17:30 – 18:30 Odd numbers: 18:30 – 19:30
19:45 -20:30 H 4/5	Keynote lecture III (on ELSA topics) K3 – Modeling mouse and human development with stem cells: the science and the ethics Nicolas Rivron, IMBA, Austrian Academy of Science, Vienna, Austria Chair: Aljoscha Berve
20:30 – 22:00 Foyer	GSCN Get-together for all participants Dinner buffet in the Foyer
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Thursday, 14 September 2023

09:00 – 10:30	Concurrent scientific working group session II
09:00 – 10:30 H 1	Stem cells in disease modeling & drug development II (Chairs: Bert Klebl / Harald Stachelscheid)
09:00 – 09:15	T16 – TPP1 gene therapy ablates disease phenotype in neuronal ceroid lipofuscinosis type 2 in retinal organoid and retina-on-chip models Kevin Achberger, University of Tübingen
09:15 – 09:30	T17 – A human iPSC model of Tauopathies engineered for adult Tau isoform expression displays late-stage neuronal Tau pathology Angelika Dannert, Ludwig Maximilians University (LMU), Munich
09:30 – 09:45	T18 – Beyond cell-autonomous phenotypes: multi-compartment modeling of human nociception Pascal Röderer, University of Bonn
09:45 – 10:00	T19 – An isogenic human iPSC model unravels neurodevelopmental abnormalities in spinal muscular atrophy Natalia Rodriguez-Muela, German Center for Neurodegenerative Diseases (DZNE), Dresden
10:00 – 10:15	T20 – Characterizing the neurotoxic effects of paclitaxel in human induced pluripotent stem cell (iPSC)-derived sensory neurons in a multi-omic approach Christian Schinke, Charité – Berlin University Medicine
10:15 – 10:30	T21 – Modeling metastatic cancer niches for drug discovery using human iPSC-derived brain organoids Ole Pless, Fraunhofer ITMP Hamburg
09:00 – 10:30 H 2	Stem cell organoids (Chairs: Sina Bartfeld / Mina Gouti)
09:00 – 09:30	T22 – 3D electrically excitable cell networks – from brain to heart Maria-Patapia Zafeiriou, University Medical Center Göttingen
09:30 – 09:45	T23 – Inducing lung differentiation in human heart-forming organoids to form complex lung-HFOs Lika Drakhlis, Hannover Medical School (MHH)
09:45 – 10:00	T24 – Development of a skin cancer model using melanoma tumor spheroids and skin organoids Dieter Groneberg, Fraunhofer-Institute for Silicate Research ISC, Würzburg
10:00 – 10:15	T25 – Modeling Johanson-Blizzard syndrome (JBS) in a dish – molecular insights into UBR1 deficiency using pluripotent stem cell-derived pancreatic organoids Leon Reichardt, Ulm University
10:15 – 10:30	T26 – Generating fetal liver organoids with innate immunopoiesis from human pluripotent stem cells Milad Rezvani, Charité – Berlin University Medicine
09:00 – 10:30 H 3	Stem cells in ageing & disease (Chairs: Michael Rieger / Andreas Trumpp)
09:00 – 09:30	T27 – Bone marrow stromal dysregulations in clonal hematopoiesis and related myelodysplasia promote an inflammatory-stress T cell landscape Borhane Guezguez, DKTK – University Medical Center Mainz
09:30 – 09:45	T28 – Ontogenetic and functional heterogeneity of tissue resident macrophages during aging and systemic inflammation Stephan Culemann, Leibniz Institute on Aging/FLI, Jena
09:45 – 10:00	T29 – Single-cell barcoding delineates a differentiation hierarchy of leukemia-initiating stem cells in adult acute lymphoblastic leukemia Alec Geßner, Goethe University Hospital, Frankfurt
10:00 – 10:15	T30 – Stem cell-niche interactions control leukemic expansion: conceptual insights from the mathematical modeling of acute myeloid leukemia Ingmar Glauche, Technical University (TU) Dresden
10:15 – 10:30	T31 – Elevated levels of Ube2g1 expression in HSCs leads to premature aging of the hematopoietic system Julian Niemann, Ulm University
09:00 – 10:30 tbd	ELSA symposium: What makes it (not) a human being? (Chairs: Aljoscha Berve / Tobias Cantz) Panelists: Nicolas Rivron & Hiromitsu Nakauchi
09:00 – 09:05	Welcome and introduction Tobias Cantz, Hannover Medical School
09:05 – 09:15	*Interview Nicolas Rivron* with Aljoscha Berve, Stemcell Network NRW, Düsseldorf** What is your definition of embryoids, blastoids, self-assembled embryos and do these differences matter? Do you think the term “synthetic embryo” is justified”? What are your expectations on advanced embryoid cultivation in 10 years? How do differing international regulations affect your current research? Do you experience global differences in acceptance / funding options of your research?
09:15 – 09:25	Interview Hiromitsu Nakauchi with Tobias Cantz What are your expectations on the use of human-animal chimera for organ development in 10 years? If an organ is generated by embryo complementation with patient-derived iPS cells. Who owns the organ? Germline contribution of human cells is a critical issue. But to what extent does neural chimerism matter? How do differing international regulations affect your current research? Do you experience global differences in acceptance / funding options of your research?
09:25 – 10:15	Panel discussion / plenum: What characteristics are missing to make an embryoid a human being? And, what is missing to make a chimeric animal a human being? Subsequent to the term “synthetic embryo”, do we have to contemplate the term “synthetic human being”? Are there “safety switches” that would address major doubts? Could we envision a road map that guides a step-wise development advanced embryoids human-animal chimeras?
10:15 – 10:20	Concluding remarks Aljoscha Berve
10:20 – 10:30	Civey survey on embryo research regulation in Germany How does the German (internet) public feel about embryo research regulation? Daniel Besser
10:30 – 11:00	Break time / Industry exhibition supported by Axion BioSystems
11:00 – 12:30	Industry session: "Technologies from GSCN industry partners"
11:00 – 12:30 H 4/5	Gold & Silver Supporter (Chair: Michael Cross)
11:00 – 11:30	C01 – Life & Brain integrated services: molecular karyotyping for cost-effective quality control of stem cell systems Michael Peitz, Life & Brain GmbH
11:30 – 12:00	C02 – Enhanced genetic stability of human pluripotent stem cells maintained as single cells under optimized culture conditions Kimberly Snyder, STEMCELL Technologies Inc., Vancouver, BC, Canada
12:00 -12:30	C03 – Replace, Reduce, and Refine with Bio-Techne – kick-start your animal-free research Simon Sumer, Bio-Techne
11:00 – 12:30 H 1	Silver Supporter (Chair: Michaela Frye)
11:00 – 11:30	C04 – Rapid and consistent generation of functional hiPSC-derived microglia to accelerate drug discovery for neurodegenerative diseases Malathi Raman, bit.bio
11:30 – 12:00	C05 – Establishing an exosome isolation process – from stirred 3D-stem cell cultures to efficient isolation Philipp Nold, Eppendorf SE
12:00 – 12:30	C06 – Highly customizable single-use bioreactors paving the way towards precision medicine Parinaz Ashrafi, Dirk Otter, Getinge
11:00 – 12:30 H2	Silver & Bronze Supporter (Chair: Ulrich Martin)
11:00 – 11:30	C07 – Efficient and seamless reprogramming using mRNA Sebastian Knöbel, Miltenyi Biotec B.V. & Co. KG
11:30 – 12:00	C08 – Identification of an FXR-modulated liver-intestine hybrid state in IPSC-derived hepatocyte-like cells Patrick Nell, IfaDo, Dortmund for Takara Bio Europe, SAS
12:00 – 12:15	C09 – Next generation cytogenomics with optical genome mapping: quality assessment for cell bioprocessing Julika Borde, Bionano
12:15 – 12:30	C10 – Chemically defined biomatrices for efficient isolation and manufacturing of stem cells Richard Wetzel, denovoMATRIX GmbH
11:00 – 12:30 H 3	Bronze Supporter (Chair: Nico Lachmann)
11:00 – 11:15	C11 – Gentle single-cell isolation technologies for generating clonal hiPSC cultures with market-leading efficiencies Alex Feuerborn, iotaSciences
11:15 – 11:30	C12 – Reliable 3D Cell Models – High-Yield Cultivation Meets Precision Sorting Markus Uhrig, OLS OMNI Life Science GmbH & Co. KG
11:30 – 11:45	C13 – In vitro differentiation of human pluripotent stem cells: role in pancreatic development and diabetes research Sandra Heller, Universitätsklinik Ulm for PeproTech GmbH, part of Thermo Fisher Scientific
11:45 – 12:00	C14 – A large-scale standardized production workflow of 3D organoids and their use in high-throughput screening applications Christian Holz, Molecular Devices (Germany) GmbH
12:00 – 12:15	C15 – Development of a Real-Time Assay for Tracking the Proliferation of iPSCs and iPSCderived Organoids Linda Boekestijn, Axion BioSystems
12:15 -12:30	C16 – Process development for efficient CAR T cell manufacturing using a closed and modular instrument workflow Xavier De Mollerat Du Jeu, Thermo Fisher Scientific
12:30 – 14:00	Lunch break / Industry exhibition supported by Molecular Devices GmbH
14:00 – 16:15 H 4/5	Presidential Symposium Chair: Claudia Waskow
14:00 – 14:45	Presidential Invite PS1 – Understanding and treating diabetes with islet stem cell models Maike Sander, Max Delbrück Center Berlin
14:45 – 15:15	GSCN 2023 Young Investigator Award PS2 – Dissecting pancreatic progenitor heterogeneity and early dysplasia using human pluripotent stem cells Meike Hohwieler, University of Ulm
15:15 – 15:45	GSCN 2023 Hilde Mangold Award PS3 – Modeling pancreas development with organoids Anne Grapin-Botton, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
15:45 – 16:15	GSCN Publication of the Year 2022 – 2023 Award PS4 – Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging Ruzhica Bogeska, German Cancer Research Center (DKFZ), Heidelberg
16:15 – 16:30	Break time / Industry exhibition supported by iotaSciences
16:30 – 18:30 Foyer	Poster session II (Poster number P062 – P122) supported by Peprotech GmbH (with beverages) Computational stem cell biology: P062 – P066 Hematopoietic stem cells: P067 – P077 Pluripotency & reprograming: P078 – P084 Stem cells in aging & disease: P085 – P099 Stem cells in regenerative therapies: P100 – P122 Even numbers: 16:30 – 17:30 Odd number: 17:30 – 18:30
19:00 – 01:00	GSCN networking event for all participants supported by STEMCELL Technologies GmbH The entrance fee is collected on site Event location: ➚ Wiley Club Wileystraße 4, 89231 Neu-Ulm

Friday, 15 September 2023

09:00 – 10:30	Concurrent scientific working group session III
09:00 – 10:30 H 1	Stem cell in regenerative therapies supported by Eppendorf SE (Chairs: Michael Cross / Wolfgang Wagner)
09:00 – 09:30	T32 – Advances in iPSC-based cellular therapies – preclinical evaluation and clinical trials Ulrich Martin, Hannover Medical School (MHH)
09:30 – 09:45	T33 – iPSC-derived cultured red blood cells resemble fetal liver erythropoiesis Isabel Dorn, Medical University Graz
09:45 – 10:00	T34 – Dissecting alpha and beta cell fate specification during human endocrinogenesis Melis Akgün, Helmholtz Center Munich
10:00 – 10:15	T35 – Inhibition of fatty acid oxidation impairs satellite cell quiescence and muscle regeneration by blocking the nuclear Acetyl-CoA production and histone acetylation Xuejun Yuan, MPI for Heart and Lung Research, Bad Nauheim
10:15 – 10:30	T36 – Grafting postmitotic induced neurons: toward the establishment of defined human neuronal 3D networks Jasmin Aicher, University of Bonn
09:00 – 10:30 H 2	Hematopoietic stem cells (Chairs: Simon Haas / Michael Milsom)
09:00 – 09:30	T37 – Deciphering how mitochondrial state impacts on hematopoietic stem cell fate Els Mansell, Erasmus MC, Rotterdam, Netherlands
09:30 – 09:45	T38 – Hematopoietic stem and progenitor cell motility and cytoskeletal dynamics Germán Camargo Ortega, ETH Zürich, Basel, Switzerland
09:45 – 10:00	T39 – Aging of human HSC niche and its impact on HSC function Ani Grigoryan, Ulm University
10:00 – 10:15	T40 – tba Jasmin Rettkowski, MPI for Immunobiology and Epigenetics, Freiburg
10:15 – 10:30	T41 – Embryonic macrophages regulate the size of the definitive HSC pool Gülce Percin, Leibniz Institute on Aging / FLI, Jena
09:00 – 10:30 H 3	Somatic stem cells & development (Chairs: Thomas Braun / Ana Martin-Villalba)
09:00 – 09:18	T42 – Dynamics and functions of widespread RNA isoform changes during neuronal cell differentiation Andreas Mayer, MPI for Molecular Genetics, Berlin
09:18 – 09:36	T43 – Unraveling heterogeneity and dynamics of muscle stem cell niches through integration of single-cell transcriptomics and advanced imaging Josephine Bageritz, COS Heidelberg University
09:36 – 09:54	T44 – Genetic dissection of in vivo direct cellular reprogramming Ismail Özcan, University of Hamburg
09:54 – 10:12	T45 – Spatial transcriptomics reveal asymmetric cellular responses to injury in the regenerating spiny mouse (Acomys) ear Kerstin Bartscherer, Osnabrück University
10:12 – 10:30	T46 – Derivation of human fetal-derived neuroepithelial progenitors mirroring the early stages of human brain development Marcel Tisch, University of Innsbruck, Austria
10:30 – 11:00	Break time / Industry exhibition
11:00 – 12:30	Concurrent strategic working group session
11:00 – 12:30 H 4/5	Clinical trials & regulatory affairs (Chairs: Zoltan Ivics / Torsten Tonn)
11:00 – 11:30	S1 – Developing a national strategy for gene and cell therapy Christopher Baum, Berlin Institute of Health (BIH) at Charité
11:30 – 12:00	S2 – Stakeholders perspectives on the national strategy on gene and cell therapy Zoltan Ivics, Paul Ehrlich Institute, Langen
12:00 – 12:30	S3 – Regulatory support in product development Christoph Conrad, Berlin Institute of Health (BIH) at Charité
11:00 – 12:30 H 2	Career development (Chairs: Germán Camargo / Insa Schröder)
	S4 – Power abuse in academia – what‘s the problem and what can be done? Karin Höhne, Berlin Institute of Health (BIH) at Charité
11:00 – 12:30 H 3	Technologies in stem cell research (Chairs: Andreas Bosio / Sebastian Diecke)
11:00 – 11:30	EMBO YIP Lecture S5 – Clonally resolved single-cell multi-omics of leukemic and hematopoetic stem cells Lars Velten, Centre for Genomic Regulation (CRG), Barcelona, Spain
11:30 – 12:00	S6 – Spatio-temporal, optogenetic control of gene expression in stem cells and organoids Ivano Legnini, Human Technopole, Milano, Italy
12:00 – 12:30	S7 – Temporal topography of malignant brain tumors Dieter Henrik Heiland, University hospital Freiburg
12:30 – 14:00	Lunch break / Industry exhibition supported by Bionano
14:00 – 14:45 H 4/5	Keynote lecture IV & EMBO Keynote Lecture K4 – Differentiation and dedifferentiation in mammalian epidermis Fiona Watt, EMBL Heidelberg Chair: Mareike Essers
14:45 – 15:30 H 4/5	Keynote lecture V K5 – Multilayer control of plant stem cell behavior Jan Lohmann, COS University Heidelberg Chair: Heiko Lickert
15:30 – 15:50	Poster award ceremony Daniel Besser Poster awards supported by Getinge Travel awards supported by Bio-Techne
15:50 – 16:00	Closing remarks by the GSCN president Claudia Waskow
	End of GSCN Conference 2023
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