Program

Main Hall (MH); Red Hall (RH); White Hall front (WHf); White Hall rear (WHr); Gallery (GA)

Tuesday, 13 September 2023

14:00 – 14:30 MH	Opening GSCN Conference 2023
14:00 – 14:10	Welcome to Münster and to Halle Münsterland Angela Stähler, Major of Münster
14:10 – 14:25	Greeting from the BMBF Representative, Federal Ministry of Education and Research (BMBF)
14:25 – 14:30	Opening of GSCN Conference 2022 Hans Schöler, President GSCN
14:30 – 15:15 MH	Keynote lecture I supported by Sartorius K1 – Stem cells in the adult brain: regulation and diversity Fiona Doetsch, Biocenter Basel, Switzerland Chair: Heiko Lickert
15:15 – 16:00 MH	Keynote lecture II K2 – Decoding the mechanisms governing human hematopoietic stem cell specification and self-renewal Hanna Mikkola, University of California, Los Angeles, USA Chair: Claudia Waskow
16:00 – 16:30	Break time / Industry exhibition
16:30 – 18:30 GA	Poster session I (Poster number P001-P091, X01) supported by Stem Genomics (with beverages) Stem cells in regenerative therapies: P001 – P027 Somatic stem cells & development: P028 – P034 Pluripotency & reprograming: P035 – P056 Organoids: new models for diseases: P057 – P091 Even numbers: 16:30 – 17:30 Odd numbers: 17:30 – 18:30
	Evening at leisure
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Wednesday, 14 September 2022

09:00 – 10:30	Concurrent scientific working group session I
09:00 – 10:30 RH	Organoids: new models for diseases supported by Takara (Chairs: Sina Bartfeld / Heiko Lickert)
09:00 – 09:30	T01 – Human gastric organoids reveal Helicobacter pylori tropism to differentiated pit cells dependent on chemotaxis Sina Bartfeld, TU Berlin
09:30 – 09:45	T02 – A compartimentalized assembloid model of the optic nerve Kevin Achberger, Uni Tübingen
09:45 – 10:00	T03 – SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids Yotam Menuchin-Lasowski, MPI for Molecular Biomedicine, Münster
10:00 – 10:15	T04 – Human hematopoietic liver organoids as model platform of multi-lineage hepatogenesis and complex hepatitis Milad Rezvani, Charité Berlin
10:15 – 10:30	T05 – Deep learning for high-throughput microscopy image analysis of organoids Dominik Waibel, Helmholtz Zentrum Munich
09:00 – 10:30 WHf	Stem cells in regenerative therapies (Chairs: Ulrich Martin / Wolfgang Wagner)
09:00 – 09:30	T06 – IDUNN trial – mesenchymal stromal cells (MSC) “MC0518” for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGvHD) Lisa-Marie Pfeffermann, DRK Blood Donor Service, Frankfurt
09:30 – 09:45	T07 – Continuous production of hiPSC-derived natural killer cells and dendritic cells using a concurrent differentiation platform Fawaz Saleh, Hannover Medical School (MHH)
09:45 – 10:00	T08 – Mesenchymal stromal cell-derived extracellular: Immunomodulatory and pro-regenerative drugs of the future? Bernd Giebel, University hospital Essen
10:00 – 10:15	T09 – Contribution of human stem cell-derived cardiomyocytes subtypes to bioartificial cardiac tissue formation and function Veronika Fricke, Hannover Medical School (MHH)
10:15 – 10:30	T10 – Microglia cell therapy to treat CNS manifestations in lysosomal storage diseases Christoph Patsch, BlueRock Therapeutics, Heidelberg
09:00 – 10:30 WHr	Stem cells in aging & disease supported by bio‑techne (Chairs: Hartmut Geiger / Andreas Trumpp)
09:00 – 09:30	T11 – Dormancy, diapause and senescence in stem cells and cancer Andreas Trumpp, DKFZ Heidelberg
09:30 – 09:45	T12 – Cellular age is accelerated in myeloproliferative neoplasms Vithurithra Tharmapalan, University hospital RWTH Aachen
09:45 – 10:00	T13 – Single-cell multi-omics unveils transcriptional regulation of the hematopoietic response to sepsis Alessandro Greco, DKFZ Heidelberg
10:00 – 10:15	T14 – Immunomodulation by resident neural stem cells suppresses chronic inflammation Yu-Hsuan Chu, University Freiburg
10:15 – 10:30	T15 – Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cycle Damian Carvajal Ibanez, DKFZ Heidelberg
10:30 – 11:00	Break time / Industry exhibition supported by Peprotech
11:00 – 12:00 RH	GSCN General Membership Meeting Executive Board & Managing Director Hans Schöler, Claudia Waskow, Hartmut Geiger, Michael Cross, Andreas Trumpp, Daniel Besser
12:00 – 13:30	Lunch break / Industry exhibition supported by Evotec
13:30 – 18:05 MH	20 Years Stem Cell Network NRW Anniversary Symposium Chair: Oliver Brüstle
13:30 – 13:40 MH	Welcome to the Anniversary Symposium Oliver Brüstle, Institute of Reconstructive Neurobiology, University of Bonn
13:40 – 13:50 MH	Welcome from the Ministry of Culture and Science of North Rhine-Westphalia
13:50 – 14:35 MH	Keynote lecture NRW01 – Stem cell technologies for the study of Huntingtin structure-function relationship and striatal neurons development and pathogenesis at single-cell resolution Elena Cattaneo, National Institute of Molecular Genetics, Milan, Italy
14:35 – 14:40	Short break
14:40 – 16:00 MH	NRW scientific session I (Chairs: Peter Horn / Martin Zenke)
14:40 – 15:05	NRW02 – Cerebral organoids to model developmental brain pathologies in vitro Julia Ladewig, Hector Institute for Translational Brain Research (HITBR) Central Institute of Mental Health, University of Heidelberg
15:05 – 15:30	NRW03 – Epigenetic biomarkers to track differentiation of pluripotent stem cells Wolfgang Wagner, Institute for Stem Cell Biology, Aachen University Medical School
15:30 – 15:45	NRW04 – Cell-cell communication promotes extraembryonic lineage differentiation in embryo-like stem cell aggregates Christian Schröter, MPI for Molecular Physiology, Dortmund
15:45 – 16:00	NRW05 – Human forebrain brain organoids assembling bilateral eye primordia Jay Gopalakrishnan, Heinrich Heine University, Düsseldorf
16:00 – 16:30	Break time / Industry exhibition
16:30 – 18:05 MH	NRW scientific session II (Chairs: Andreas Faissner / Edda Tobiasch)
16:30 – 16:55	NRW06 – Ribosomes are decision hubs for early embryonic cell fate decisions Leo Kurian, University of Cologne
16:55 – 17:20	NRW07 – Multicellular coordination in context Takashi Hiiragi, Hubrecht Institute Utrecht, The Netherlands
17:20 – 17:35	NRW08 – Epigenetic and transcriptomic changes during blood-to-neural stem cell conversion: Transcription factor-induced de-aging? Lea Jessica Flitsch, University of Bonn
17:35 – 17:50	NRW09 – Enteroviruses modulate the cellular HCN4 channel trafficking and alter electrochemical signal generation in hiPSC-derived pacemaker-like cells Stefan Peischard, University Hospital Münster
17:50 – 18:05	NRW10 – Reprograming-driven drug discovery identifies an efficacious repurposing candidate for the treatment of Leigh syndrome patients Annika Zink, Heinrich Heine University, Düsseldorf
18:05 – 18:30	Break time / Industry exhibition
18:30 – 19:15 MH	Keynote lecture III (ELSA) K3 – Risk ethics and the future of genome editing Dieter Birnbacher, Heinrich Heine University, Düsseldorf Chair: Tobias Cantz
19:15 – 21:00	GSCN Get-together for all participants Dinner buffet in the Foyer
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Thursday, 15 September 2022

09:00 – 10:30	Concurrent scientific working group session II
09:00 – 10:30 RH	Stem cell in disease modeling & drug development I (Chairs: Oliver Brüstle / Bert Klebl)
09:00 – 09:30	T16 – Exploring the role of FOXF2 in small vessel disease (SVD) in a human iPSC-derived model of the neurovascular unit (NVU) Dominik Paquet, LMU/DZNE Munich
09:30 – 09:45	T17 – Assessing developmental neurotoxicity of paracetamol using human neural progenitor cells and cortical spheroids Mohamad Hajo, University of Bonn
09:45 – 10:00	T18 – Patient-derived stem cells to study the pathology of autism spectrum disorders-related voltage-gated calcium channel gain-of-function mutations Marcel Tisch, University of Innsbruck
10:00 – 10:15	T19 – hiPSC-derived adrenocortical cell model reveals the pathophysiology of KCNJ5 mutation in primary aldosteronism Kieu Nhi Tran Vo, Charité/BIH, Berlin
10:15 – 10:30	T20 – Novel tools for enhancing stem cell-based modeling of pain disorders Pascal Röderer, University of Bonn
09:00 – 10:30 WHf	Hematopoietic stem cells (Chairs: Michael Rieger / Claudia Waskow)
09:00 – 09:30	T21 – Somatic mutations in hematopoietic stem cells: competitive advantage and organ interplay in clonal hematopoiesis Michael Rieger, Goethe University, Frankfurt a.M.
09:30 – 09:45	T22 – Hematopoietic progenitors drive human macrophage ontogeny from pluripotent stem cells Nico Lachmann, Hannover Medical School (MHH)
09:45 – 10:00	T23 – Aged or trained – hematopoietic stem and progenitor cells after recovery from respiratory infection Marcel G.E. Rommel, Paul-Ehrlich-Institute, Langen
10:00 – 10:15	T24 – The response of the murine niche to donor human HSC in NSGW41 mice Nina Henning, Leibniz Institute on Aging (FLI), Jena
10:15 – 10:30	T25 – Long-term ex vivo hematopoietic stem cell (HSC) expansion using novel bone-lining reinvigorating mesenchymal stromal cells (rMSCs) Shubhankar Sood, DKFZ Heidelberg
09:00 – 10:30 WHr	Somatic stem cells & development (Chairs: Thomas Braun / Ana Martin-Villalba)
09:00 – 09:30	T26 – Targeting RNA modifications in disease Michaela Frye, DKFZ Heidelberg
09:30 – 09:45	T27 – Transition-state, branch-point associated cells give rise to the majority of ciliated cells in the mouse lung Keynoosh Khalooghi, MPI for Heart and Lung Research, Bad Nauheim
09:45 – 10:00	T28 – Chemical hPSC cardiac progenitor’s stabilization in vitro reflects stage-specific heart development in vivo Emiliano Bolesani, Hannover Medical School (MHH)
10:00 – 10:15	T29 – Embryonic progenitors undergo a behavioral change on the way to becoming adult stem cells in the medaka retina Natalia Sokolova, COS University Heidelberg
10:15 – 10:30	T30 – Stem cell niche formation induces stereotypical organogenesis in Drosophila ovary Ana-Maria Zamfirescu, Hannover Medical School (MHH)
09:00 – 12:30 Gallery 2	ELSA Symposium Ethical discussions on early embryonic entities, gender classifications and genome editing Organizers: Aljoscha Berve / Tobias Cantz
10:30 – 11:00	Break time / Industry exhibition supported by Synthego
11:00 – 12:30	Industry session: "Technologies from GSCN industry partners"
11:00 – 12:30 MH	Gold & Silver Supporter (Chairs: Michael Cross / Sira Groscurth)
11:00 – 11:30	C01 – Advancements in modeling disease efficiently Karthi Rajamani, Takara Bio Europe, SAS
11:30 – 12:00	C02 – CellCelector – automated clonal colony picking and single cell cloning for stem cell applications Jens Eberhardt, Sartorius
12:00 – 12:30	C03 – Advanced hPSC bioprocessing in stirred tank bioreactors Robert Zweigerdt, Hannover Medical School (MHH) for Eppendorf SE
11:00 – 12:30 RH	Silver Supporter (Chairs: Hannes Klump / Richard Schäfer)
11:00 – 11:30	C04 – Boost your stem cell culture workflow with Bio-Techne Simon Sumer, bio-techne
11:30 – 12:00	C05 – Robust workflows for the expansion of pluripotent stem cells in 3D suspension culture Camille Lemey, STEMCELL Technologies
12:00 – 12:30	C06 – High-Content, high-throughput imaging and analysis of intestinal organoid arrays Robert Storm, Molecular Devices GmbH
11:00 – 12:30 WHf	Bronze Supporter I (Chairs: Sebastian Diecke / Ingo Roeder)
11:00 – 11:15	C07 – A revolutionary benchtop platform improving viability, yield and long-term culture of 3D cell models Amir Keric, OLS OMNI Life Science GmbH & Co. KG
11:15 – 11:30	C08 – Process- and cell specific biomimetic matrices enable culture of functional stem cells Sandra Segeletz, denovoMATRIX GmbH
11:30 – 11:45	C09 – Development of novel tools and technologies for cardiovascular research Dominik Eckardt, Miltenyi Biotec B.V. & Co. KG
11:45 – 12:00	C10 – Revolutionizing drug discovery for neurological disorders through precision medicine Sandra Lubitz, Evotec SE
12:00 – 12:15	C11 – Why you should routinely test the genomic integrity of your cell lines Agnes Miermont, Stem Genomics
11:00 – 12:30 WHr	Bronze Supporter II (Chairs: Michael Rieger / Claudia Waskow)
11:00 – 11:15	C12 – Why you should give a HEK: advantages of human derived cytokines and growth factors Rebecca Northeast, Proteintech Group
11:15 – 11:30	C13 – 3D stem cell culture: use of mixed reality to support your learning Tim Wessel, Thermo Fisher Scientific
11:30 – 11:45	C14 – Functional connectivity of sympathetic neurons with cardiomyocytes in a human iPSC-derived innervated cardiac muscle model Maria-Patapia Zafeiriou, University Medical Center Göttingen for Peprotech GmbH
11:45 – 12:00	C15 – A new method for the automated enumeration and analysis of CD34+ hematopoietic stem and progenitor cells by flow cytometry Andreas Böhmler, Beckman Coulter GmbH
12:00 – 12:15	C16 – Industrialized CRISPR iPS cells enable Alzheimer’s disease modeling effort at scale for NIH’s iNDI Project Kai Wilkens, Synthego
12:30 – 14:00	Lunch break / Industry exhibition supported by Beckman Coulter
13:00 – 14:00	Meet-the-expert tables (limited to 10 participants each, registration is possible at the registration desk) Simon Haas, Ulrich Martin
14:00 – 16:15 MH	Presidential Symposium Chairs: Oliver Brüstle / Hans Schöler
14:00 – 14:45	Presidential Invite & EMBO Keynote Lecture PS1 – Recent progress in iPS cell research and application Shinya Yamanaka, Center for iPS Cell Research and Application (CiRA), Kyoto, Japan, EMBO Associate Member
14:45 – 15:15	GSCN 2022 Young Investigator Award PS2 – Single-cell systems understanding of the hematopoietic stem cell system in health and disease Simon Haas, Max Delbrück Center/BIMSB & BIH, Berlin
15:15 – 15:45	GSCN 2022 Hilde Mangold Award & EMBO YIP Lecture PS3 – Liver organoids to study regeneration and cancer across biological scales Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
15:45 – 16:15	GSCN Publication of the Year 2021 – 2022 Award PS4 – Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity Fatma Uzbas, Helmholtz Zentrum Munich
16:15 – 16:30	Break time / Industry exhibition
16:30 – 18:30 GA	Poster session II (P092 – P179, X02 – X05) supported by Miltenyi (with beverages) Stem cells in disease modeling & drug development: P092 – P144 Stem cells in aging & disease: P145 – P157 Hematopoietic stem cells: P158 – P171 Computational stem cell biology & systems biology: P172 – P179 Even numbers: 16:30 – 17:30 Odd number: 17:30 – 18:30
19:30 – 01:00	GSCN networking event for all participants The entrance fee is collected on site Event location: ➚ Heaven Münster Am Hawerkamp 29a, 48155 Münster
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Friday, 16 September 2022

09:00 – 10:30	Concurrent scientific working group session III
09:00 – 10:30 RH	Stem cell in disease modeling & drug development II (Chairs: Julian Grünewald / Karl-Ludwig Laugwitz) supported by Molecular Devices
09:00 – 09:30	T31 – Engineered CRISPR prime editors with compact, untethered reverse transcriptases Julian Grünewald, Klinikum rechts der Isar, TU Munich
09:30 – 09:45	T32 – LZTR1 oligomerization drives Noonan syndrome-linked cardiac pathology in patient-derived and CRISPR-corrected iPSCs Alexandra Busley, University Medical Center, Göttingen
09:45 – 10:00	T33 – Evaluation of potential therapeutic approaches for PPCS deficiency-associated dilated cardiomyopathy in patient iPSC models Sarah Kübler, Klinikum rechts der Isar, TU Munich
10:00 – 10:15	T34 – Insights into the pathophysiology of Aicardi-Goutières syndrome implementing CRISPR/Cas9-engineered iPSCs as an experimental model Nina Hein-Fuchs, Paul Ehrlich Institute, Langen
10:15 – 10:30	T35 – Modeling Langerhans cell histiocytosis using induced pluripotent stem cells Giulio Abagnale, Children’s Cancer Research Institute, Vienna, Austria
09:00 – 10:30 WHf	Pluripotency & reprograming (Chairs: Ivan Bedzhov / Micha Drukker)
09:00 – 09:30	T36 – In vitro generation of germ cells: implications for fertility and healthy longevity Vittorio Sebastiano, University of Stanford, CA, USA
09:30 – 09:45	T37 – Enhancing Sox/Oct cooperativity delivers high-grade developmental reset Sergiy Velychko, MPI for Molecular Biomedicine, Münster
09:45 – 10:00	T38 – Skeletal muscle organoids recapitulate fetal myogenesis and provide a system to model Duchenne muscular dystrophy Holm Zaehres, Ruhr University, Bochum
10:00 – 10:15	T39 – Pre-mRNA splicing rules that program cardiac contractility Deniz Bartsch, University Clinics Cologne
10:15 – 10:30	T40 – Uncovering a novel myogenic regulator that facilitates reprogramming of fibroblasts into functional myogenic progenitor cells Giada Bacchin, Swiss Federal Institute of Technology (ETH) Zurich
09:00 – 10:30 WHr	Computational stem cell biology & systems biology (Chairs: Georg Fuellen / Carsten Marr)
09:00 – 09:30	T41 – Predicting the future state of differentiating cells Laleh Haghverdi, Max Delbrück Center, Berlin
09:30 – 09:45	T42 – Mathematical modeling of chronic lymphocytic leukemia cell kinetics under therapy with Ibrutinib Melanie Schulz, Helmholtz Zentrum Munich
09:45 – 10:00	T43- Expression kinetics of differentiating mouse embryonic stem cells Fabian Titz-Teixeira, University Cologne
10:00 – 10:15	T44 – Lifetime dynamics of haematopoietic stem cell clones inferred from Polylox barcoding Maurice Langhinrichs, DKFZ Heidelberg
10:15 – 10:30	T45 – Upon stem cell maturation, deregulation of epigenetic marks is correlated to differential exon usage of developmental genes Volkhard Helms, Saarland University, Saarbrücken
10:30 – 11:00	Break time / Industry exhibition supported by denovoMATRIX
11:00 – 12:30	Concurrent strategic working group session
11:00 – 12:30 RH	Clinical trials & regulatory affairs (Chairs: Andreas Kurtz / Torsten Tonn)
11:00 – 11:30	S1 – Perspectives on the immunological assessment of autologous, homozygous, and hypoimmunogenic iPSCs Micha Drukker, Leiden University
11:30 – 12:00	S2 – NK cells as carriers for chimeric antigen receptor (CAR) for targeted cancer immunotherapies Torsten Tonn, TU Dresden, DRK Blood donor service North-East
12:00 – 12:30	S3 -The new Clinical Trials Regulation (EU) No 536/2014 Jan Paus, Ethics Committee of the Westphalia-Lippe Medical Association, Münster
11:00 – 12:30 WHf	Career development (Chairs: Marieke Essers / Karin Höhne)
11:00 – 11:45	S4 – Towards responsible research for bench scientists Ulf Tölch, BIH Quest at Charité, Berlin
11:45 – 12:30	Panel discussion
11:00 – 12:30 WHr	Technologies in stem cell research (Chairs: Andreas Bosio / Sebastian Diecke)
11:00 – 11:30	S5 – Hematopoietic stem cell dynamics inferred from large-scale genomic sequencing data sets Jamie Blundell, Hutchinson-MRC Research Center, Cambridge, UK
11:30 – 12:00	S6 – Measuring somatic mutations and consequences by single cell and single strand sequencing Ashley Sanders, Max Delbrück Center (MDC-BIMSB), Berlin
12:00 – 12:30	S7 – The short and long story of sequencing for stem cell quality control Franz-Josef Müller, University Clinics Schleswig-Hostein (UKSH), Kiel
12:30 – 14:00	Lunch break / Industry exhibition supported by Thermo Fisher Scientific
13:00- 14:00	Meet-the-expert-table (limited to 10 registered participants each, registration is possible at the registration desk) Michaela Frye, Wolfgang Wagner
14:00 – 14:45 MH	Keynote lecture IV & Pro-Scientia-Award ceremony K4- Beta cell development and regeneration Heiko Lickert, Helmholtz Zentrum München Chair: Sara Wickström Award ceremony: Rudolf Tauber, Eckhart-Buddecke-Stiftung
14:45 – 15:30 MH	Keynote lecture V K5 – Reconstitution of reproductive organs including germ cells using mouse pluripotent stem cells Katsuhiko Hayashi, Kyushu University, Fukuoka, Japan Chair: Ivan Bedzhov
15:30 – 15:50	Poster award ceremony Daniel Besser Poster awards supported by Eppendorf Travel awards supported by STEMCELL Technologies
15:50 – 16:00	Closing remarks by the incoming GSCN president Claudia Waskow
	End of GSCN Conference 2022
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